Effect of haemodialysis on retinal circulation in patients with end stage renal disease
Effect of haemodialysis on retinal circulation in patients with end stage renal disease
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DOI：
10.1136/bjo.2003.039073
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发表时间：
2004-08-01
影响因子：
4.1
通讯作者：
Yoshida, A
中科院分区：
文献类型：
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作者：
Nagaoka, T;Takeyama, Y;Yoshida, A
目的：探讨血液透析对终末期肾病（ESRD）患者视网膜循环的影响。方法：连续招募17名ESRD患者参与研究。作者使用激光多普勒测速系统同时测量了 ESRD 患者血液透析前后血管直径和血流速度的变化，并计算了视网膜静脉中的视网膜血流量 (RBF)。此外，还检查了全身和视网膜循环参数变化之间的关系。结果：血液透析后，一组血管直径平均增加（p = 0.003）。然而，血液透析后获得的血流速度和RBF值与血液透析前没有显着差异（分别为p = 0.66和p = 0.63）。血管直径的变化与MABP的变化呈负相关（r=20.549，p=0.02），但血流速度和RBF的变化与MABP的变化呈正相关（分别为r=0.683，p，0.002和r=0.589，p<0.01）。 RBF的变化也与血细胞比容的增加（r=-0.693，p<0.002）和液体排出量（r=-0.597，p<0.01）呈负相关。 结论：结果表明，血液透析和相关的全身循环参数的变化可能影响ESRD患者的视网膜循环。
Aims: To investigate the effect of haemodialysis on retinal circulation in patients with end stage renal disease ( ESRD).Method: Seventeen consecutive patients with ESRD were recruited into the study. The authors simultaneously measured changes in vessel diameter and blood velocity and calculated the retinal blood flow (RBF) in the retinal veins in patients with ESRD before and after haemodialysis using a laser Doppler velocimetry system. In addition, the relations between the changes in systemic and retinal circulatory parameters were examined.Results: There was a group averaged increase in vessel diameter ( p = 0.003) after haemodialysis. However, the blood velocity and RBF values obtained after haemodialysis were not significantly different from those before haemodialysis ( p = 0.66 and p = 0.63, respectively). The changes in vessel diameter were negatively ( r = 20.549, p = 0.02) correlated with the change in MABP, but the changes in blood velocity and RBF were positively correlated with the change in MABP ( r = 0.683, p, 0.002 and r = 0.589, p< 0.01, respectively). The change in RBF was also inversely correlated with the increase in haematocrit ( r = -0.693, p< 0.002) and the amount of fluid removed ( r = -0.597, p< 0.01).Conclusion: The results indicate that haemodialysis and the associated changes in systemic circulatory parameters may affect the retinal circulation in patients with ESRD.