Significance of fetal hemoglobin-containing erythroblasts (F blasts) and the F blast/F cell ratio in myelodysplastic syndromes
Significance of fetal hemoglobin-containing erythroblasts (F blasts) and the F blast/F cell ratio in myelodysplastic syndromes
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DOI：
10.1038/sj.leu.2402536
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发表时间：
2002-08-01
期刊：
影响因子：
11.4
通讯作者：
Ito, M
中科院分区：
文献类型：
--
作者：
Choi, JW;Yim, Y;Ito, M
为探讨骨髓增生异常综合征（MDS）患者的胎儿含血红蛋白成红细胞（F母细胞）与细胞凋亡的关系，我们对137例MDS患者的IF母细胞、IF细胞和细胞凋亡进行了化学检测。137例患者中有116例（84.7%）骨髓中F原始细胞数量明显增加，54例（39.4%）F细胞数量升高。在抗血型糖蛋白C抗体染色的成红细胞中，MDS组F母细胞的平均百分比为14.63 ± 9.17%，显著高于非MDS伴应激性红细胞生成的患者（4.82 ± 3.35%，P < 0.01），但两组间IF细胞的数量无显著差异。特别是，137例MDS患者中有62例（45.3%）IF原始细胞明显增加，但F细胞无升高。IF母细胞/F细胞（Fb/Fc）比值大于或等于5.0的患者的凋亡率显著高于Fb/Fc比值大于或等于5.0的患者。
To investigate the relationship between the fetal hemoglobin-containing erythroblasts (F blasts) and apoptosis in myelodysplastic syndromes (MDS), we immunohistochemically assessed IF blasts, IF cells, and apoptosis in 137 patients with MDS. A marked increase in the number of F blasts in the bone marrow was identified in 116 of 137 patients (84.7%), and the number of F cells was elevated in 54 patients (39.4%). Among the erythroblasts stained by anti-glycophorin C antibody, the mean percentage of F blasts was 14.63 +/- 9.17% in MDS, which was significantly higher than that in non-MDS patients with stress erythropoiesis (4.82 +/- 3.35%, P < 0.01), although there were no significant differences in the number of IF cells between these groups. In particular, 62 of the 137 MDS patients (45.3%) had an apparent increase in IF blasts but no elevation of F cells. The apoptotic rate was significantly higher in the patients with a IF blast/F cell (Fb/Fc) ratio greater than or equal to5.0 than in those with a Fb/Fc ratio