Unraveling the Detoxification Mechanism of 2,4-Dichlorophenol by Marine-Derived Mesophotic Symbiotic Fungi Isolated from Marine Invertebrates
Unraveling the Detoxification Mechanism of 2,4-Dichlorophenol by Marine-Derived Mesophotic Symbiotic Fungi Isolated from Marine Invertebrates
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DOI：
10.3390/md17100564
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发表时间：
2019-10-01
期刊：
影响因子：
5.4
通讯作者：
Topakas, Evangelos
中科院分区：
文献类型：
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作者：
Nikolaivits, Efstratios;Agrafiotis, Andreas;Topakas, Evangelos
氯酚类化合物（Chlorophenols，CPs）是由人类活动产生并进入环境的环境污染物。包括人类在内的生物体暴露于这些有毒的异生物质，并遭受不利的健康影响。更具体地说，2，4-二氯苯酚（2，4-DCP）在环境中的释放量很高，已被美国环境保护署列为优先污染物。生物修复已被提议作为一种可持续的替代传统的补救方法的酚类化合物的解毒。在这项工作中，我们研究了潜在的真菌菌株分离的海洋无脊椎动物的共生体，从未开发的中光珊瑚生态系统。因此，这些真菌菌株的非特异性代谢途径正在探索在本研究中，使用强大的分析能力的UHPLC-HRMS/MS。新鉴定的2，4-DCP代谢物添加显着的知识，这些污染物的转化真菌，因为这样的报告是稀缺的。
Chlorophenols (CPs) are environmental pollutants that are produced through various anthropogenic activities and introduced in the environment. Living organisms, including humans, are exposed to these toxic xenobiotics and suffer from adverse health effects. More specifically, 2,4-dichlorophenol (2,4-DCP) is released in high amounts in the environment and has been listed as a priority pollutant by the US Environmental Protection Agency. Bioremediation has been proposed as a sustainable alternative to conventional remediation methods for the detoxification of phenolic compounds. In this work, we studied the potential of fungal strains isolated as symbionts of marine invertebrates from the underexplored mesophotic coral ecosystems. Hence, the unspecific metabolic pathways of these fungal strains are being explored in the present study, using the powerful analytical capabilities of a UHPLC-HRMS/MS. The newly identified 2,4-DCP metabolites add significantly to the knowledge of the transformation of such pollutants by fungi, since such reports are scarce.