Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19
Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19
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DOI：
10.1016/j.cell.2020.08.017
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发表时间：
2020-10-01
期刊：
影响因子：
64.5
通讯作者：
Buggert, Marcus
中科院分区：
文献类型：
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作者：
Sekine, Takuya;Perez-Potti, Andre;Buggert, Marcus
SARS-CoV-2 特异性记忆 T 细胞可能对针对 COVID-19 的长期免疫保护至关重要。在这里，我们系统地绘制了未暴露个体、暴露家庭成员以及急性或恢复期 COVID-19 个体中 SARS-CoV-2 特异性 T 细胞反应的功能和表型图谱。急性期 SARS-CoV-2 特异性 T 细胞表现出高度激活的细胞毒性表型，与疾病严重程度的各种临床标志物相关，而恢复期 SARS-CoV-2 特异性 T 细胞具有多功能性，并表现出干细胞样记忆表型。重要的是，在抗体血清阴性暴露的家庭成员和有无症状且轻度 COVID-19 病史的恢复期个体中可检测到 SARS-CoV-2 特异性 T 细胞。我们的集体数据集显示，SARS-CoV-2 引发广泛定向且功能丰富的记忆 T 细胞反应，这表明自然暴露或感染可能会预防严重 COVID-19 的复发。
SARS-CoV-2-specific memory T cells will likely prove critical for long-term immune protection against COVID-19. Here, we systematically mapped the functional and phenotypic landscape of SARS-CoV-2-specific T cell responses in unexposed individuals, exposed family members, and individuals with acute or convalescent COVID-19. Acute-phase SARS-CoV-2-specific T cells displayed a highly activated cytotoxic phenotype that correlated with various clinical markers of disease severity, whereas convalescent-phase SARS-CoV-2-specific T cells were polyfunctional and displayed a stem-like memory phenotype. Importantly, SARS-CoV-2-specific T cells were detectable in antibody-seronegative exposed family members and convalescent individuals with a history of asymptomatic and mild COVID-19. Our collective dataset shows that SARS-CoV-2 elicits broadly directed and functionally replete memory T cell responses, suggesting that natural exposure or infection may prevent recurrent episodes of severe COVID-19.