Gastric infusion of short-chain fatty acids can improve intestinal barrier function in weaned piglets

Gastric infusion of short-chain fatty acids can improve intestinal barrier function in weaned piglets
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胃液输注短链脂肪酸可改善断奶仔猪肠道屏障功能

DOI:
10.1186/s12263-019-0626-x
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发表时间:
2019-02-01
影响因子:
3.5
通讯作者:
Chen, D. W.
Chen, D. W.
中科院分区:
医学2区
文献类型:
--
作者:
Diao, H.;Jiao, A. R.;Chen, D. W.

文献摘要

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本研究旨在探讨短链脂肪酸(SCFA)灌胃对猪模型肠屏障功能的影响。本试验选用初产体重为8.310.72 kg的21头DLY公牛,随机分为3个处理:(1)对照组,(2)低SCFA饲喂组,(1)高SCFA饲喂组,(3)高SCFA饲喂组。结果灌胃SCFA可提高血清和消化中SCFA的浓度,增加猪肠组织中SCFA受体的mRNA和蛋白丰度(P
BackgroundThe present study was conducted to investigate the effects of gastric infusion of short-chain fatty acids (SCFA) on gut barrier function in a pig model. In this study, 21 DLY barrows with an average initial body weight of (8.310.72) kg were randomly allotted into three treatments: (1) control, (2) infusing low SCFA, S1, (3) infusing high SCFA, S2. The experimental period lasted for 7days.ResultsGastric infusion of SCFA increased the concentrations of SCFA in serum and digesta, and enhanced the mRNA and protein abundances of SCFA receptors in pig intestine (P