Interaction between Mesenchymal Stem Cells and B-Cells.
Interaction between Mesenchymal Stem Cells and B-Cells.
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DOI：
10.3390/ijms17050650
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发表时间：
2016-05-05
影响因子：
5.6
通讯作者：
Li L
中科院分区：
文献类型：
--
作者：
Fan L;Hu C;Chen J;Cen P;Wang J;Li L
间充质干细胞（MSC）是多能的;非造血干细胞。由于其免疫调节能力，MSC被广泛用于不同的临床应用。与其他免疫细胞相比，MSC如何特异性调节B细胞的研究一直是肤浅和不足的。此外，关于这种调节的少数实验研究往往是矛盾的。在这次审查中;我们总结了不同类型或状态的间充质干细胞和B细胞之间的各种相互作用;解决不同类型的间充质干细胞和B细胞如何影响这种相互作用，并检查其他免疫细胞如何影响间充质干细胞对B细胞的调节。最后，我们假设为什么在文献中MSC和B细胞之间的相互作用有相互矛盾的结果。
Mesenchymal stem cells (MSCs) are multipotent; non-hematopoietic stem cells. Because of their immunoregulatory abilities; MSCs are widely used for different clinical applications. Compared with that of other immune cells; the investigation of how MSCs specifically regulate B-cells has been superficial and insufficient. In addition; the few experimental studies on this regulation are often contradictory. In this review; we summarize the various interactions between different types or states of MSCs and B-cells; address how different types of MSCs and B-cells affect this interaction and examine how other immune cells influence the regulation of B-cells by MSCs. Finally; we hypothesize why there are conflicting results on the interaction between MSCs and B-cells in the literature.