OLIG2 as a specific marker of oligodendroglial tumour cells
OLIG2 as a specific marker of oligodendroglial tumour cells
复制标题
DOI：
10.1016/s0140-6736(01)05499-x
复制
发表时间：
2001-07-28
期刊：
影响因子：
168.9
通讯作者：
Khê, HX
中科院分区：
文献类型：
--
作者：
Marie, Y;Sanson, M;Khê, HX
OLIG2是最近鉴定的参与少突胶质细胞谱系中细胞的特化的转录因子。我们通过原位杂交研究了21例脑肿瘤中OLIG2的表达：9例II级和III级少突胶质细胞瘤，3例II级少突星形细胞瘤和9例非少突胶质细胞瘤（4例IV级星形细胞瘤，2例脑膜瘤，1例胚胎发育不良性神经上皮肿瘤和2例转移瘤）。在所有少突胶质细胞瘤和少突星形细胞瘤中均存在对应于肿瘤性少突胶质细胞的OLIG2阳性细胞。相比之下，在非少突胶质细胞肿瘤中未检测到OLIG2表达。因此，少突胶质细胞瘤可能起源于少突胶质细胞前体细胞。OLIG2应该被证明是诊断少突胶质细胞肿瘤的有用标志物。
OLIG2 is a recently Identified transcription factor involved In the specification of cells In the oligodendroglial lineage. We Investigated the expression of OLIG2 by In-situ hybridisation In 21 brain tumours: nine grade II and III oligodendrogliomas, three grade II oligoastrocytomas, and nine non-oligodendroglial tumours (four grade IV astrocytomas, two meningiomas, a dysembryoplastic neuroepithelial tumour, and two metastases). OLIG2-positive cells corresponding to neoplastic oligodendrocytes were present in all oligodendrogliomas and oligoastrocytomas. By contrast, OLIG2 expression was not detected in the non-oligodendroglial tumours. Thus, oligodendroglioma probably arise from oligodendrocyte precursor cells. OLIG2 should prove a useful marker for the diagnosis of oligodendroglial tumours.