Pharmacokinetics of levetiracetam in neonates with seizures.

Pharmacokinetics of levetiracetam in neonates with seizures.
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DOI:
10.1016/j.jpeds.2011.03.057
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发表时间:
2011-07
影响因子:
5.1
通讯作者:
Vinks, Alexander A.
Vinks, Alexander A.
中科院分区:
医学2区
文献类型:
--
作者:
Merhar, Stephanie L.;Schibler, Kurt R.;Sherwin, Catherine M.;Meinzen-Derr, Jareen;Shi, Jing;Balmakund, Tonya;Vinks, Alexander A.

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The pharmacokinetics of levetiracetam were determined prospectively in 18 neonates with seizures. Neonates were found to have lower clearance, higher volume of distribution, and a longer half-life as compared with older children and adults. Mild somnolence was the only adverse effect.
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