Single nonfouling hydrogels with mechanical and chemical functionality gradients
Single nonfouling hydrogels with mechanical and chemical functionality gradients
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DOI：
10.1016/j.biomaterials.2011.07.062
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发表时间：
2011-11-01
期刊：
影响因子：
14
通讯作者：
Jiang, Shaoyi
中科院分区：
文献类型：
--
作者：
Carr, Louisa R.;Krause, Jordan E.;Jiang, Shaoyi
水凝胶作为组织工程支架被广泛研究，但它们被设计用于模拟的生物组织通常是具有不均匀化学和机械特征的复杂组织。这项工作报告了一种新的策略，以创建水凝胶组成的一个单一的无污染的，但功能化的材料与机械和/或化学功能梯度的连续片材。通过使用不结垢的羧基甜菜碱甲基丙烯酸酯（CBMA）和羧基甜菜碱二甲基丙烯酸酯交联剂（CBMAX）的可官能化或不可官能化形式的不同组合，可以产生具有交联密度和/或可官能化基团梯度的各种水凝胶。在这项工作中，我们证明了这一概念与两个不结垢的水凝胶，都具有机械梯度：一个具有均匀的functionalizability和其他化学functionalizability的梯度。有了这个多功能的系统，水凝胶与内置的各种类型的梯度分布可以控制在一个给定的应用程序。(C)2011爱思唯尔有限公司保留所有权利。
Hydrogels are widely studied as tissue engineering scaffolds, but the biological tissues they are designed to mimic are often complex tissues with non-uniform chemical and mechanical profiles. This work reports a new strategy to create hydrogels composed of a continuous sheet of a single nonfouling but functionalizable material with mechanical and/or chemical functionality gradients. By using different combinations of functionalizable or nonfunctionalizable versions of nonfouling carboxybetaine methacrylate (CBMA) and carboxybetaine dimethacrylate crosslinker (CBMAX), various hydrogels with gradients of crosslinking densities and/or functionalizable groups can be created. In this work, we demonstrate this concept with two nonfouling hydrogels, both with a mechanical gradient: one with uniform functionalizability and the other with a gradient in chemical functionalizability. With this versatile system, hydrogels with built-in gradient profiles of various types can be controlled at will for a given application. (C) 2011 Elsevier Ltd. All rights reserved.