The effect of electroacupuncture as an adjunct on cyclophosphamide-induced emesis in ferrets
The effect of electroacupuncture as an adjunct on cyclophosphamide-induced emesis in ferrets
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DOI：
10.1016/s0091-3057(02)01069-9
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发表时间：
2003-02-01
影响因子：
3.6
通讯作者：
Berman, BM
中科院分区：
文献类型：
--
作者：
Lao, LX;Zhang, G;Berman, BM
本实验采用不同电刺激参数（5-100 Hz，1.5~3 V，5-20 min，n = 6/组），观察电针内关穴（P6）对环磷酰胺所致雪貂呕吐的影响。电针联合疗法（100 Hz，1.5 V和10 min）与较低剂量的昂丹司琼（0.04 mg/kg），氟哌利多（0.25 mg/kg）和甲氧氯普胺（2.24 mg/kg）分别使呕吐发作总数显著减少52%、36%和73%，以及第一阶段的呕吐发作次数与假针刺对照组相比（P
The effect of electroacupuncture (EA) on cyclophosphamide-induced emesis in ferrets was studied at acupuncture point Neiguan (P6) with various electrical stimulation parameters (5-100 Hz, 1.5-3 V, 5-20 min, n=6/group). The combination therapy of EA (100 Hz, 1.5 V and 10 min) with the lower doses of ondansetron (0.04 mg/kg), droperidol (0.25 mg/kg) and metoclopramide (2.24 mg/kg) significantly reduced the total number of emetic episodes by 52%, 36% and 73%, respectively, as well as the number of emetic episodes in the first phase as compared to the sham acupuncture control (P