Ghrelin enhances appetite and increases food intake in humans
Ghrelin enhances appetite and increases food intake in humans
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DOI：
10.1210/jc.86.12.5992
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发表时间：
2001-12-01
影响因子：
5.8
通讯作者：
Bloom, SR
中科院分区：
文献类型：
--
作者：
Wren, AM;Seal, LJ;Bloom, SR
Ghrelin是最近发现的生长激素促分泌素受体的内源性配体。它主要在胃中合成，并在健康人的血液循环中发现。Ghrelin已被证明可以促进啮齿动物的食物摄入量增加、体重增加和肥胖。Ghrelin对人的食欲和食物摄入量的影响尚未确定。我们在9名健康志愿者身上进行了一项随机双盲交叉研究，调查了静脉注射Ghrelin(5.0pmol/kg/min)或生理盐水输注对食欲和食物摄入量的影响。每个人从自由选择的自助餐中消耗的能量明显增加(平均增加28+/-3.9%，p
Ghrelin is a recently identified endogenous ligand for the growth hormone secretagogue receptor. It is synthesized predominantly in the stomach and found in the circulation of healthy humans. Ghrelin has been shown to promote increased food intake, weight gain and adiposity in rodents. The effect of ghrelin on appetite and food intake in man has not been determined. We investigated the effects of intravenous ghrelin (5.0 pmol/kg/min) or saline infusion on appetite and food intake in a randomised double-blind cross-over study in nine healthy volunteers. There was a clear-cut increase in energy consumed by every individual from a free-choice buffet (mean increase 28 +/- 3.9%, p