Endocrine actions of pesticides measured in the Flemish environment and health studies (FLEHS I and II)
Endocrine actions of pesticides measured in the Flemish environment and health studies (FLEHS I and II)
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DOI：
10.1007/s11356-014-3437-z
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发表时间：
2015-10-01
影响因子：
5.8
通讯作者：
Baeyens, W.
中科院分区：
文献类型：
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作者：
Croes, K.;Den Hond, E.;Baeyens, W.
在佛兰德环境与健康研究（FLEHS I，2002-2006年，和FLEHS II，2007-2012年）中，对居住在弗兰德斯（比利时）的14-15岁青少年的农药接触、激素水平和性成熟程度进行了测量。在FLEHS II中，发现p，p '-二氯苯二氯乙烯（p，p'-DDE）和六氯苯（HCB）的几何平均浓度（95%置信区间（CI））分别为307（277-341）和36.5 ng L-1（34.0-39.2）。这些值分别比5年前FLEHS I的水平低26%和60%。在FLEHS II中首次测量了有机磷农药（OPPs）和对二氯苯的代谢物，二甲基磷酸盐和二乙基磷酸盐代谢物和2，5-二氯苯酚（2，5-DCP）的总和的浓度分别为11.4、3.27和1.57 μ g L-1。关于体内接触六氯苯的数据表明，男孩的性成熟、睾酮和芳香化酶指数与游离甲状腺素（fT 4）和促甲状腺激素（TSH）（男孩和女孩）呈正相关。研究发现，p，p '-DDE和六氯苯与女孩的性发育呈负相关，而β-DDE代谢物与男孩血液中的性激素水平和性成熟（男孩和女孩）呈负相关。农药代谢物2，5-DCP与游离T4呈负相关，而与TSH呈正相关（男孩和女孩）。这些结果表明，即使暴露于相对低浓度的农药也会对14-15岁青少年的激素水平和性成熟程度产生重大影响。
Within the Flemish Environment and Health studies (FLEHS I, 2002-2006, and FLEHS II, 2007-2012), pesticide exposure, hormone levels and degree of sexual maturation were measured in 14-15-year-old adolescents residing in Flanders (Belgium). In FLEHS II, geometric mean concentrations (with 95 % confidence interval (CI)) of 307 (277-341) and 36.5 ng L-1 (34.0-39.2) were found for p,p'-dichlorophenyldichloroethylene (p,p'-DDE) and hexachlorobenzene (HCB). These values were respectively 26 and 60 % lower than levels in FLEHS I, 5 years earlier. Metabolites of organophosphorus pesticides (OPPs) and of para-dichlorobenzene were measured for the first time in FLEHS II, yielding concentrations of 11.4, 3.27 and 1.57 mu g L-1 for the sum of dimethyl- and diethyl phosphate metabolites and 2,5-dichlorophenol (2,5-DCP), respectively. Data on internal exposure of HCB showed a positive correlation with sexual maturation, testosterone and the aromatase index for boys and with free thyroxine (fT4) and thyroid stimulating hormone (TSH) (both boys and girls). For both p,p'-DDE and HCB, a negative association with sexual development in girls was found. The OPP metabolites were negatively associated with sex hormone levels in the blood of boys and with sexual maturation (both boys and girls). The pesticide metabolite 2,5-DCP was negatively correlated with free T4, while a positive association with TSH was reported (boys and girls). These results show that even exposure to relatively low concentrations of pesticides can have significant influences on hormone levels and the degree of sexual maturation in 14-15-year-old adolescents.