High Oscillospira abundance indicates constipation and low BMI in the Guangdong Gut Microbiome Project
High Oscillospira abundance indicates constipation and low BMI in the Guangdong Gut Microbiome Project
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DOI：
10.1038/s41598-020-66369-z
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发表时间：
2020-06-09
影响因子：
4.6
通讯作者：
Yang, Zhi-cong
中科院分区：
文献类型：
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作者：
Chen, Yi-ran;Zheng, Hui-min;Yang, Zhi-cong
颤螺旋菌是一种常见但很少培养的肠道细菌属。最近人类肠道微生物群的研究已经证明了其对宿主健康的潜在意义。然而，很少有人知道有关的主机信息和Oscillospira和肠道微生物群落的其他成员之间的联系。为了研究颤螺旋藻的生态学并深入了解颤螺旋藻相关宿主的生理条件，我们分析了广东肠道微生物组项目的数据，该项目是目前最大的肠道微生物数据库之一。对6376名参与者的数据进行了分析。我们研究了颤螺旋体的流行率和相对丰度以及相关微生物群落的概况。我们发现颤螺旋体与人类健康密切相关，因为它的丰度与微生物多样性、高密度脂蛋白、睡眠时间呈正相关，与舒张压、收缩压、空腹血糖、甘油三酯、尿酸和布里斯托粪便类型呈负相关。此外，具有五重交叉验证的随机森林分析显示，颤螺旋菌可能是亚组中低BMI和便秘的预测因子。总体而言，在这项研究中，我们提供了一个基本的了解示波螺旋相关的微生物群概况和宿主的生理参数。我们的研究结果表明，颤螺旋体可能在加重便秘中发挥作用。
Oscillospira is a common yet rarely cultivated gut bacterial genus. Recently human gut microbiota studies have demonstrated its underlying significance for host health. However, little is known about Oscillospira-related host information and the links between Oscillospira and other members of the gut microbial community. To study the ecology of Oscillospira and gain insights into Oscillospira-related host physiological conditions, we analyzed data from the Guangdong Gut Microbiome Project, one of the largest gut microbiota database currently. Data of 6376 participants were analyzed. We studied the prevalence and relative abundance of Oscillospira as well as the profiles of associated microbial communities. We found that Oscillospira is closely related to human health because its abundance was positively correlated with microbial diversity, high density lipoprotein, and sleep time, and was inversely correlated with diastolic blood pressure, systolic blood pressure, fasting blood glucose, triglyceride, uric acid and Bristol stool type. Moreover, random forest analysis with five-fold cross validation showed Oscillospira could be a predictor of low BMI and constipation in the subset. Overall, in this study, we provide a basic understanding of Oscillospira-related microbiota profile and physiological parameters of the host. Our results indicate Oscillospira may play a role in aggravating constipation.