An enhancing effect of the antihistaminic drug methapyrilene on rat liver carcinogenesis by previously administered N-2-fluorenylacetamide.
An enhancing effect of the antihistaminic drug methapyrilene on rat liver carcinogenesis by previously administered N-2-fluorenylacetamide.
复制标题
通过预先施用 N-2-芴基乙酰胺，增强抗组胺药物甲吡林对大鼠肝癌发生的作用。
DOI：
10.1016/0041-008x(83)90178-3
复制
发表时间：
1983
影响因子：
3.8
通讯作者：
Williams,GM
中科院分区：
文献类型：
--
作者：
Furuya,K;Mori,H;Williams,GM
本文研究了抗组胺药物甲基吡喃(MP)和典型的肝肿瘤促进剂苯巴比妥(PB)在遗传毒性肝癌致癌剂N-2-荧乙酰胺(FAA)后顺序给药对小鼠肝癌发生的影响。最初暴露于饮食中0.02%的FAA 8周，以产生肝细胞病变灶。基础饮食多维持24周的大鼠发生肝脏肿瘤的几率较低。在FAA后，饮食中500和1000ppm的MP在FAA后24周增加了早期病变和后期肝肿瘤的发生率，PB也是如此。MP和PB单独都不会产生肿瘤，但MP单独会产生显著的病灶改变发生率。因此，这些结果为MP的促进作用提供了证据，但其致癌作用可能涉及额外的作用。
The effect on hepatocarcinogenesis of sequential administration of the antihistaminic drug methapyrilene (MP) or the typical liver tumor promoter, phenobarbital (PB), each given after the genotoxic liver carcinogen, N-2-fluorenylacetamide (FAA) was studied. An initial exposure to 0.02% of FAA in the diet for 8 weeks was used to produce hepatocellular altered foci. Rats maintained for an additional 24 weeks on basal diet developed a low incidence of liver neoplasms. MP at 500 and 1000 ppm in the diet for 24 weeks after FAA increased the frequency of altered foci at early stages and liver neoplasms later, as did PB. Neither MP nor PB alone produced neoplasms, but MP alone produced a significant incidence of altered foci. Therefore, the results provide evidence for a promoting action of MP, but additional effects may be involved in its carcinogenicity.