Regioselectivity in palladium-catalyzed C-H activation/oxygenation reactions
Regioselectivity in palladium-catalyzed C-H activation/oxygenation reactions
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DOI：
10.1021/ol051486x
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发表时间：
2005-09-15
期刊：
影响因子：
5.2
通讯作者：
Sanford, MS
中科院分区：
文献类型：
--
作者：
Kalyani, D;Sanford, MS
在一系列间位取代的芳基吡啶和芳基酰胺衍生物中探索了钯催化的定向C-H活化/氧化反应。这些转换容忍各种各样的供电子和吸电子间位取代基，并通常进行高水平的区域选择性官能化的空间位阻较小的邻位-C-H键。
Palladium-catalyzed directed C-H activation/oxygenation reactions have been explored in a series of meta-substituted aryl pyridine and aryl amide derivatives. These transformations tolerate a diverse array of electron-donating and electron-withdrawing meta-substituents and generally proceed with high levels of regioselectivity for functionalization of the less sterically hindered ortho-C-H bond.