Age-related effects of smoking on lung cancer mortality: A nationwide case-control comparison in 103 population centers in China
Age-related effects of smoking on lung cancer mortality: A nationwide case-control comparison in 103 population centers in China
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DOI：
10.1016/j.annepidem.2008.01.004
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发表时间：
2008-06-01
影响因子：
5.6
通讯作者：
Li, Junyao
中科院分区：
文献类型：
--
作者：
Jiang, Jingmei;Liu, Boqi;Li, Junyao
目的：在一项大规模人群病例对照研究中，探讨吸烟对肺癌死亡率与年龄相关的影响，该研究被纳入中国全国死亡率回顾性调查。方法：本次分析汇集了两个数据集：全国死亡率调查数据和全国病例对照比较数据。这些汇总数据用于根据吸烟状况和每次吸烟相关死亡的预期预期寿命损失年数来计算特定年龄的肺癌死亡率。 结果：35至69岁男性吸烟者的死亡人数明显过多（城市死亡人数为54%，农村死亡人数为51%），这些年龄段每名与吸烟相关死亡的平均预期寿命损失为18.3年。对于年龄 35 至 69 岁的女性，城市和农村吸烟者的肺癌死亡率分别高出 29% 和 11%，每次与吸烟相关的死亡平均预期寿命损失 21.3 年。 结论：吸烟与大量肺癌死亡相关。利用基于人群的回顾性死亡率调查的信息对疾病的主要决定因素进行流行病学分析研究是可行的，并且可以产生重要的结果。
PURPOSE: To examine age-related effects of smoking on lung cancer mortality in a large population-ased case-control study that was incorporated into a nationwide retrospective survey of mortality in China.METHODS: Two data sets were pooled for this analysis: national mortality survey data and data from a nationwide case-control comparison. These pooled data were used to calculate age-specific lung cancer death rates by smoking status and expected years of lost life expectancy for each smoking,associated death.RESULTS: There was a significant excess of deaths (54% of urban deaths, 51% of rural deaths) at 35 to 69 years of age among male smokers and the average loss of life expectancy per smoking-associated death at these ages was 18.3 years. For women ages 35 to 69 years of age, 29% and 11% excess lung cancer mortality was observed in urban and rural smokers, respectively, with an average loss of life expectancy per smoking-associated death of 21.3 years.CONCLUSIONS: Tobacco smoking was associated with a large number of deaths from lung cancer. Utilizing information from a population-based retrospective mortality survey for conducting an analytic epidemiological study of main determinants of disease is feasible and can generate important results.