The anatomy of conscious vision: an fMRI study of visual hallucinations
The anatomy of conscious vision: an fMRI study of visual hallucinations
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DOI：
10.1038/3738
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发表时间：
1998-12-01
影响因子：
25
通讯作者：
Williams, S
中科院分区：
文献类型：
--
作者：
Ffytche, DH;Howard, RJ;Williams, S
尽管功能性神经影像学最近取得了进展，但我们如何以及在哪里看到的这个看似简单的问题视觉意识的神经生物学继续挑战着神经科学家。由于没有一种方法来区分意识和无意识传入感觉信号的特定神经处理，这个问题很难通过实验来解决。在这里，我们使用功能性磁共振成像（fMRI）来研究查尔斯邦纳综合征的患者，对他们来说，视觉感知和感觉输入已经分离。我们发现，颜色、面孔、纹理和物体的幻觉与腹侧纹外视皮层的大脑活动相关，幻觉的内容反映了该区域的功能专业化，幻觉患者的腹侧纹外活动增加，这种活动在幻觉之间持续存在。
Despite recent advances in functional neuroimaging, the apparently simple question of how and where we see-the neurobiology of visual consciousness-continues to challenge neuroscientists. Without a method to differentiate neural processing specific to consciousness from unconscious afferent sensory signals, the issue has been difficult to resolve experimentally. Here we use functional magnetic resonance imaging (fMRI) to study patients with the Charles Bonnet syndrome, for whom visual perception and sensory input have become dissociated. We found that hallucinations of color, faces, textures and objects correlate with cerebral activity in ventral extrastriate visual cortex, that the content of the hallucinations reflects the functional specializations of the region and that patients who hallucinate have increased ventral extrastriate activity, which persists between hallucinations.