Incorporation of PLLA micro-fillers for mechanical reinforcement of calcium-phosphate cement
Incorporation of PLLA micro-fillers for mechanical reinforcement of calcium-phosphate cement
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DOI：
10.1016/j.jmbbm.2017.03.027
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发表时间：
2017-07-01
影响因子：
3.9
通讯作者：
van den Beucken, Jeroen J. J. P.
中科院分区：
文献类型：
--
作者：
Castro, Antonio G. B.;Polini, Alessandro;van den Beucken, Jeroen J. J. P.
磷酸钙骨水泥 (CPC) 具有生物相容性、可吸收性、可注射性和骨传导性。这些特性使得此类材料适用于需要骨修复和再生的应用。然而，它们的脆性性质限制了它们仅适用于非承重应用。长聚合物纤维的加入可以提高 CPC 的机械性能，但聚集是一个主要问题。相反，短聚合物填料可以很容易地分散在水泥基体中，但其增强效果尚未得到研究。在本研究中，通过静电纺丝制备了具有光滑或多孔表面形态的连续聚（L）-乳酸纤维（PLLA）。 PLLA 微填料是通过氨解工艺开发的，并添加到基于 α-TCP 或 α-TCP/PLGA 的水泥中。评估了微填料的分布以及形态、内聚性、凝固时间和机械性能。 PLLA 微填料均匀地分散在整个水泥中，同时处理性能没有受到显着影响。当添加 PLLA 时，观察到初始凝固时间减少，而机械性能与 α-TPC 或 α-TCP/PLGA 组合物的机械性能相当。
Calcium phosphate cements (CPCs) are biocompatible, resorbable, injectable and osteoconductive. Those properties render such materials suitable for applications where bone repair and regeneration is required However, their brittle nature limits their application only to non-load-bearing applications. The incorporation of long polymeric fibers can improve the mechanical properties of CPCs, but aggregation is a major problem. Instead, short polymeric fillers can be easily dispersed in the cement matrix, but their reinforcing effect has not been studied yet. In this study, continuous poly-(L)-lactic acid fibers (PLLA) with a smooth or porous surface morphology were prepared by electrospinning. PLLA micro-fillers were developed, by means of an aminolysis process, and added to alpha-TCP or alpha-TCP/PLGA-based cements. Micro-filler distribution as well as the morphology, cohesiveness, setting times and mechanical properties were evaluated. PLLA micro-fillers were homogeneously dispersed throughout the cement while the handling properties were not significantly affected. A decrease in the initial setting times was observed when PLLA was added, while the mechanical properties were comparable to those of the alpha-TPC or alpha-TCP/PLGA compositions.