Th17 and allergy.
Th17 and allergy.
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DOI：
10.2332/allergolint.r-07-160
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发表时间：
2008-06-01
期刊：
影响因子：
--
通讯作者：
Nakae, Susumu
中科院分区：
文献类型：
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作者：
Oboki, Keisuke;Ohno, Tatsukuni;Nakae, Susumu
新的辅助性T（Th）细胞亚群的鉴定，即，产生IL-17的Th细胞（Th 17细胞）和调节性T细胞（Treg细胞）为我们理解感染性和自身免疫性疾病以及免疫应答的发展所涉及的分子机制提供了新的见解，从而导致经典Th 1/Th 2范式的修订。目前来自基因缺陷小鼠的几条证据表明，IL-17和Th 17细胞，而不是IFN-γ和Th 1细胞，是导致自身免疫性疾病如鼠关节炎和脑脊髓炎发展的原因，这些疾病通常被认为是Th 1介导的疾病。Th 17细胞也可能有助于经典公认的Th 2介导的过敏性疾病的发病机制。本文就IL-17和Th 17细胞在变态反应性疾病发病机制中的作用进行综述。
The identification of novel helper T (Th) cell subsets, i.e., IL-17-producing Th cells (Th17 cells) and regulatory T cells (Treg cells), provided new insight into our understanding of the molecular mechanisms involved in the development of infectious and autoimmune diseases as well as immune responses, and thus led to revision of the classic Th1/Th2 paradigm. Several current lines of evidence from gene-deficient mice indicate that IL-17 and Th17 cells, but not IFN-gamma and Th1 cells, are responsible for the development of autoimmune diseases such as murine arthritis and encephalomyelitis, which have classically been considered to be Th1-mediated disorders. Th17 cells may also contribute to the pathogenesis of classically recognized Th2-mediated allergic disorders. In this review, we summarize the current knowledge regarding IL-17 and Th17 cells and discuss their potential roles in the pathogenesis of allergic disorders.