Antibiotic resistance of Helicobacter pylori in Chinese children: Amulticenter retrospective study over 7years
Antibiotic resistance of Helicobacter pylori in Chinese children: Amulticenter retrospective study over 7years
复制标题
中国儿童幽门螺杆菌抗生素耐药性：7年多中心回顾性研究。
DOI：
10.1111/hel.12373
复制
发表时间：
2017-06-01
期刊：
影响因子：
4.4
通讯作者：
Li, Youming
中科院分区：
文献类型：
--
作者：
Li, Lan;Ke, Yini;Li, Youming
背景：了解中国儿童幽门螺杆菌对甲硝唑、克拉霉素、左氧氟沙星、阿莫西林和呋喃唑酮的耐药情况。材料与方法本研究于2009年1月至2015年12月进行多中心回顾性研究。在浙江省东南沿海9个地区共分离到幽门螺杆菌1746株。采用琼脂稀释法检测幽门螺杆菌对抗生素的敏感性。结果甲硝唑的耐药率为75.20%，克拉霉素为16.38%，左氧氟沙星为6.70%，阿莫西林为0.06%，呋喃唑酮为0.06%。幽门螺杆菌抗生素耐药模式显示，7年来对克拉霉素、阿莫西林、呋喃唑酮和甲硝唑的耐药率无显著变化。随着儿童年龄的增长，甲硝唑耐药呈明显上升趋势，克拉霉素耐药呈下降趋势。不同年龄组对其他抗生素的耐药性无差异。此外，男性和女性受试者对这五种抗生素的耐药率没有显著差异。10.65%的菌株以甲硝唑和克拉霉素双耐药为主。结论东南沿海地区儿童幽门螺杆菌对甲硝唑的耐药率较高，对克拉霉素和左氧氟沙星的耐药率中等，对阿莫西林和呋喃唑酮的耐药率较低。重要的是继续监测该地区分离的幽门螺杆菌的耐药概况。
BackgroundTo determine the prevalence of resistance to metronidazole, clarithromycin, levofloxacin, amoxicillin, and furazolidone in Helicobacter pylori isolated from Chinese children.Materials and MethodsThis multicenter retrospective study was conducted from January 2009 to December 2015. A total of 1746 isolates of H. pylori were collected from nine areas of Zhejiang province in the southeast coastal region of China. H. pylori strains were examined for antibiotics susceptibility by agar dilution method.ResultsThe resistance rates were 75.20% for metronidazole, 16.38% for clarithromycin, 6.70% for levofloxacin, 0.06% for amoxicillin, and 0.06% for furazolidone. The pattern of H. pylori antibiotic resistance demonstrated no significant changes in the rates of resistance to clarithromycin, amoxicillin, furazolidone, and metronidazole over 7 years. A significant trend of increasing resistance to metronidazole was observed as children aged, but a downward trend in clarithromycin resistance was observed as children aged. No difference in the resistance to other antibiotics was observed among different age groups. Also, there was no significant difference between male and female subjects in rates of resistance to these five types of antibiotics. The predominant dual resistance to metronidazole and clarithromycin was presented in 10.65% of the isolates.ConclusionsThe resistance rates of H. pylori in children from southeast coastal region of China were very high to metronidazole, moderate to clarithromycin and levofloxacin, and low to amoxicillin and furazolidone. It is important to continue monitoring the resistance profiles of H. pylori isolated in this region.