Dissociated pathways for successful memory retrieval from the human parietal cortex: anatomical and functional connectivity analyses.
Dissociated pathways for successful memory retrieval from the human parietal cortex: anatomical and functional connectivity analyses.
复制标题
从人类顶叶皮层成功提取记忆的分离途径：解剖学和功能连接分析。
DOI：
10.1093/cercor/bhm204
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发表时间：
2008
期刊：
影响因子：
--
通讯作者：
Kim,Dae-Shik
中科院分区：
文献类型：
--
作者：
Takahashi,Emi;Ohki,Kenichi;Kim,Dae-Shik
传统上，顶叶皮质与空间注意力和眼球运动过程有关。最近的功能性神经影像学研究发现，顶叶皮层的激活与成功的再认记忆有关。被激活的区域包括外侧顶叶皮层的顶内沟和内侧顶叶皮层的楔前叶。然而，很少有人知道顶叶外侧皮层和内侧皮层在记忆提取过程中的功能差异。在这项研究中，我们研究了人类外侧和内侧顶叶是否与颞叶有不同的解剖和功能连接。为此，我们使用功能性磁共振成像来限制通过扩散张量成像（DTI）获得的解剖连接分析。DTI纤维束成像和功能连接分析均显示，顶叶外侧区与颞叶外侧区存在解剖和功能连接，顶叶内侧区与颞叶内侧区存在解剖和功能连接。这些结果表明，在成功的记忆提取中存在分离的外侧和内侧顶颞通路。
The parietal cortex has traditionally been implicated in spatial attention and eye-movement processes. Recent functional neuroimaging studies have found that activation in the parietal cortex is related to successful recognition memory. The activated regions consistently include the intraparietal sulcus in the lateral parietal cortex and the precuneus in the medial parietal cortex. However, little is known about the functional differences between lateral and medial parietal cortices in the memory retrieval process. In this study, we examined whether the human lateral and medial parietal lobes have differential anatomical and functional connectivity with the temporal lobe. To this end, we used functional magnetic resonance imaging to constrain the analysis of anatomical connectivity obtained by diffusion tensor imaging (DTI). Both DTI tractography and functional connectivity analysis showed that the lateral parietal region has anatomical and functional connections with the lateral temporal lobe, and the medial parietal region has connections with the medial temporal lobe. These results suggest the existence of segregated lateral and medial parieto-temporal pathways in successful memory retrieval.