Effects of intravenous terbutaline on heart rate, arterial pressure and blood gases in anesthetized horses breathing air
Effects of intravenous terbutaline on heart rate, arterial pressure and blood gases in anesthetized horses breathing air
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DOI：
10.1111/vaa.12377
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发表时间：
2017-01-01
影响因子：
1.7
通讯作者：
Clark-Price, Stuart C.
中科院分区：
文献类型：
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作者：
Arcaro, Isla;Fischer, Berit L.;Clark-Price, Stuart C.
目的探讨全凭静脉麻醉(TIVA)下静注特布他林对健康侧卧位呼吸环境空气的健康马PaO2、PaCO2、pH、心率(HR)和动脉压的影响。6匹马，4匹母马和2匹胶体，体重433~624 kg。方法马用赛拉津(1.0 mg kg(-1))静脉注射镇静，以放置动静脉导管。麻醉诱导采用咪达唑仑0.1 mg·kg~(-1)+氯胺酮2.2 mg·kg~(-1)，静脉滴注愈创木酚醚50 mg·kg~(-1)、氯胺酮2 mg·L~(-1)、赛拉津0.5 mg·L~(-1)，维持时间1.9±0.3 mg·kg~(-1)·h~(-1)。马匹左侧卧卧，自发地呼吸空气。分别于赛拉津镇静时、麻醉诱导后15min、特布他林(2 mg·kg~(-1))给药前、给药后即刻、给药后5、15、30min、清醒后站立时采集动脉血进行pH和血气分析。麻醉期间每隔5min记录心率、收缩压(SAP)、平均动脉压(MAP)和舒张压(DAP)。结果麻醉期间(P<；0.0001)，平均动脉血氧分压(PaO2)由基线下降至60毫米汞(P<；005)，用特布他林后无明显改善。服用特布他林后，HR增加(p=0.002)，平均动脉压、平均动脉压和平均动脉压下降(p<；0.001)，其中最大的变化发生在给药后即刻。结论特布他林(2 mg kg(-1))静脉注射不能改善动脉血氧分压，并与健康侧卧呼吸马在全肺静脉麻醉期间的不良心血管反应有关。
Objective To investigate the effects of intravenous (IV) administration of terbutaline on PaO2, PaCO2, pH, heart rate (HR) and arterial pressures in healthy, laterally recumbent horses breathing ambient air under total intravenous anesthesia (TIVA).Study design Prospective experimental study.Animals Eight healthy adult horses were enrolled. Six horses, four mares and two geldings weighing 433-624 kg, completed the study.Methods Horses were sedated with xylazine (1.0 mg kg(-1)) IV for placement of arterial and venous catheters. Anesthesia was induced with midazolam (0.1 mg kg(-1)) and ketamine (2.2 mg kg(-1)) IV and maintained with an IV infusion of guaifenesin (50 mg mL(-1)), ketamine (2 mg mL(-1)) and xylazine (0.5 mg mL(-1)) at 1.9 +/- 0.3 mL kg(-1) hour(-1). Horses were in left lateral recumbency and breathed air spontaneously. Arterial blood was collected for pH and blood gas analysis during xylazine sedation, 15 minutes after induction of anesthesia, immediately before and 5, 15 and 30 minutes after administration of terbutaline (2 mg kg(-1)), and when the horse was standing after recovery from anesthesia. HR, systolic (SAP), mean (MAP) and diastolic (DAP) arterial pressures were recorded at 5 minute intervals during anesthesia. Normal data were analyzed with ANOVA and non-normal data were analyzed with a Friedman test with a p < 0.05 considered significant.Results The mean PaO2 decreased from baseline to < 60 mmHg (8.0 kPa) during anesthesia (p < 0.0001) and did not improve after administration of terbutaline. After terbutaline administration, HR increased (p = 0.002), and SAP, MAP and DAP decreased (p < 0.001) with the greatest changes occurring immediately after terbutaline administration.Conclusions and clinical relevance Terbutaline (2 mg kg(-1)) IV did not improve PaO2 and was associated with adverse cardiovascular effects during TIVA in healthy, laterally recumbent horses breathing air.