Relation of synovitis to knee pain using contrast-enhanced MRIs.
Relation of synovitis to knee pain using contrast-enhanced MRIs.
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DOI：
10.1136/ard.2009.121426
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发表时间：
2010-10
影响因子：
27.4
通讯作者：
Felson DT
中科院分区：
文献类型：
--
作者：
Baker K;Grainger A;Niu J;Clancy M;Guermazi A;Crema M;Hughes L;Buckwalter J;Wooley A;Nevitt M;Felson DT
有人提出滑膜炎会导致关节疼痛。在非增强磁共振成像（MRI）上，滑膜增厚无法评估，并且在这些图像中，滑膜炎与疼痛的关联并不一致。
利用增强（CE）MRI评估多中心骨关节炎研究（MOST）受试者中滑膜增厚与膝关节疼痛严重程度的关系。
MOST是一项针对患有膝关节骨关节炎（OA）或处于其高风险中的人群的队列研究。535名志愿者组成的未筛选子集接受了一侧膝关节的1.5T CE MRI检查。对六个腔室的滑膜炎进行评分，并创建了一个综合评分。使用西安大略和麦克马斯特骨关节炎指数（WOMAC）疼痛量表中的最大项目评分来评估膝关节疼痛的严重程度。在整个样本以及无放射学OA的亚组中，使用逻辑回归模型调整年龄、性别、体重指数（BMI）、MRI骨髓病变和积液后，检验滑膜炎与疼痛严重程度之间的关联。
在接受CE MRI检查的535名受试者中，有454名拥有关于滑膜炎和WOMAC疼痛的完整数据。平均年龄为59岁，平均BMI为30，48%为女性。在中度疼痛的膝关节中，80%存在滑膜炎。对于膝关节疼痛，与无滑膜炎者相比，滑膜炎使患病几率增加了9.2倍。在无放射学OA的膝关节（n = 329）中，滑膜炎也与疼痛患病率增加有关。
滑膜炎与膝关节疼痛严重程度密切相关，与之前使用非增强MRI评估滑膜炎的研究结果相比，通过CE MRI能更清晰地检测到这种关联。
It has been suggested that synovitis causes joint pain. On non-contrast-enhanced MRIs synovial thickening cannot be assessed and on these images synovitis has been inconsistently associated with pain. To assess synovial thickening in relation to knee pain severity among subjects in the Multicenter Osteoarthritis Study (MOST) using contrast-enhanced (CE) MRI. MOST is a cohort study of people who have, or are at high risk of, knee osteoarthritis (OA). An unselected subset of 535 participants who volunteered underwent CE 1.5 T MRI of one knee. Synovitis was scored in six compartments and a summary score was created. Knee pain severity was assessed using the maximum item score on the Western Ontario and McMaster Osteoarthritis Index (WOMAC) pain scale. The association between synovitis and pain severity was examined using a logistic regression model adjusting for age, sex, body mass index (BMI), MRI bone marrow lesions and effusions in the whole sample and in a subgroup without radiographic OA. 454 of the 535 subjects undergoing CE MRI had complete data on synovitis and WOMAC pain. Mean age was 59 years, mean BMI 30 and 48% were women. In knees with moderate pain, 80% had synovitis. For knee pain, synovitis conferred a 9.2-fold increased odds compared with those without synovitis. In knees without radiographic OA (n=329), there was also an association of synovitis with an increased prevalence of pain. Synovitis has a strong relation with knee pain severity, an association detected more clearly with CE MRI than suggested by previous studies using non-CE MRI measures of synovitis.
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影响因子：
27.4
作者：
Hernandez-Molina, G.;Neogi, T.;Felson, D. T.
通讯作者：
Felson, D. T.
影响因子：
7
作者：
Torres, L.;Dunlop, D. D.;Sharma, L.
通讯作者：
Sharma, L.
影响因子：
--
作者：
Felson, David T.;Niu, Jingbo;Aliabadi, Piran
通讯作者：
Aliabadi, Piran
影响因子：
7
作者：
Peterfy, CG;Guermazi, A;Genant, HK
通讯作者：
Genant, HK
影响因子：
5.5
作者：
Brandt, Kenneth D.;Mazzuca, Steven A.;Buckwalter, Kenneth A.
通讯作者：
Buckwalter, Kenneth A.