Stereotypic route-tracing in experimentally caged songbirds correlates with general behavioural disinhibition
Stereotypic route-tracing in experimentally caged songbirds correlates with general behavioural disinhibition
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DOI：
10.1006/anbe.2002.2254
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发表时间：
2003-10-01
期刊：
影响因子：
2.5
通讯作者：
Smith, R
中科院分区：
文献类型：
--
作者：
Garner, JP;Mason, GJ;Smith, R
重复的、不变的和明显无功能的行为称为刻板印象，在笼子里很常见，但笼子刻板印象的机制仍然难以捉摸。我们发现，刻板印象与大脑功能改变的迹象相关，即对行为的普遍去抑制，在对接受精神刺激剂治疗的人类患者和动物的刻板印象中发现。我们研究了笼养在行为研究实验室中的蓝山雀和沼泽山雀的路线跟踪刻板印象。在实验1中，刻板印象与反应的去抑制相关，表现为消退学习中的持续反应。在实验2a中，蓝山雀的刻板印象与一项专门测量人类纹状体功能紊乱的赌博任务中重复序列的产生相关，并与自闭症和精神分裂症患者的刻板印象相关。在实验2b中，与刻板印象相关的行为去抑制也影响了沼泽山雀的食物储存行为，特别是它们对偷窃缓存的反应。在实验3中，非刻板印象的家庭笼子行为的顺序与刻板印象相关。最后，环境丰富导致的刻板印象的改变与这些改变的行为控制措施的改变相关。这些结果表明，导致刻板印象的住房条件因此改变了被关在笼子里的受试者的行为控制的许多方面，这是通过改变纹状体功能来调节的。对理解实验室、农场和动物园动物的笼子刻板印象以及基于实验室的行为实验的意义进行了讨论。我们认为，改善住房条件，使笼子里的刻板印象不会发展，将提高基于实验室的行为研究的有效性。(C)2003年，动物行为研究协会。爱思唯尔有限公司出版。保留所有权利。
Repetitive, unvarying and apparently functionless behaviours called stereotypies are common in caged animals, but the mechanisms of cage stereotypy have remained elusive. We found that stereotypies correlate with a sign of altered brain functioning, the general disinhibition of behaviour, found in stereotyping human patients and animals treated with psychostimulants. We investigated route-tracing stereotypy in blue tits, Parus caeruleus, and marsh tits, P. palustris, caged in a behavioural research laboratory. In experiment 1, stereotypy correlated with disinhibition of responses, shown as persistent responding in extinction learning. In experiment 2a, stereotypy in blue tits correlated with repetitive sequence generation on a 'gambling task' that specifically measures disinhibited striatal functioning in humans and correlates with stereotypy in autistic and schizophrenic patients. In experiment 2b, the behavioural disinhibition correlated with stereotypy also affected food-storing behaviour in marsh tits, in particular their response to cache pilfering. In experiment 3, the sequencing of nonstereotypic home cage behaviour was correlated with stereotypy. Finally, changes in stereotypy induced by environmental enrichment correlated with changes in these measures of altered behavioural control. These results suggest that housing conditions that cause stereotypy thus alter many aspects of the behavioural control of caged subjects, mediated by altered striatal functioning. The implications for understanding cage stereotypies in laboratory, farm and zoo animals, and for laboratory-based behavioural experiments, are discussed. We suggest that improving housing conditions so that cage stereotypies do not develop would enhance the validity of laboratory-based behavioural research. (C) 2003 The Association for the Study of Animal Behaviour. Published by Elsevier Ltd. All rights reserved.