Effect of soya protein on blood pressure: a meta-analysis of randomised controlled trials
Effect of soya protein on blood pressure: a meta-analysis of randomised controlled trials
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DOI：
10.1017/s0007114511000262
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发表时间：
2011-08-14
影响因子：
3.6
通讯作者：
Qin, Li-Qiang
中科院分区：
文献类型：
--
作者：
Dong, Jia-Yi;Tong, Xing;Qin, Li-Qiang
观察性研究表明，大豆食品消费与血压（BP）呈负相关。来自随机对照试验（RCT）的大豆蛋白摄入量降低血压效果的证据是不确定的。我们的目的是评估大豆蛋白摄入量在降低BR方面的有效性。在PubMed数据库中检索了截至2010年4月发表的英文RCT，比较了大豆蛋白饮食与对照饮食。我们进行了一项随机效应荟萃分析，以检查大豆蛋白对BR亚组的影响，并进行荟萃回归分析，以探索试验间异质性的可能解释。对27项随机对照试验的荟萃分析显示，大豆蛋白组与对照组相比，收缩压（SBP）平均降低2.21 mmHg（95% CI-4.10，-0.33; P=0.021），舒张压（DBP）平均降低1.44 mmHg（95% CI-2.56，-0.31; P=0.012）。大豆蛋白摄入量显著降低高血压和正常血压受试者的SBP和DBP，高血压受试者的降幅明显更大。在使用碳水化合物而不是奶制品作为对照饮食的试验中也观察到了显著和更大的BP降低。荟萃回归分析进一步揭示了治疗前BP和BP降低水平之间的显著负相关。总之，与对照饮食相比，大豆蛋白摄入量显著降低SBP和DBP，但BP降低与受试者的治疗前BP水平和用作比较的对照饮食类型有关。
Observational studies have indicated that soya food consumption is inversely associated with blood pressure (BP). Evidence from randomised controlled trials (RCT) on the BP-lowering effects of soya protein intake is inconclusive. We aimed to evaluate the effectiveness of soya protein intake in lowering BR The PubMed database was searched for published RCT in the English language through to April 2010, which compared a soya protein diet with a control diet. We conducted a random-effects meta-analysis to examine the effects of soya protein on BR Subgroup and meta-regression analyses were performed to explore possible explanations for heterogeneity among trials. Meta-analyses of twenty-seven RCT showed a mean decrease of 2.21 mmHg (95% Cl -4.10, -0.33; P=0.021) for systolic BP (SBP) and 1.44 mmHg (95% CI -2.56, -0.31; P=0.012) for diastolic BP (DBP), comparing the participants in the soya protein group with those in the control group. Soya protein consumption significantly reduced SBP and DBP in both hypertensive and normotensive subjects, and the reductions were markedly greater in hypertensive subjects. Significant and greater BP reductions were also observed in trials using carbohydrate, but not milk products, as the control diet. Meta-regression analyses further revealed a significantly inverse association between pre-treatment BP and the level of BP reductions. In conclusion, soya protein intake, compared with a control diet, significantly reduces both SBP and DBP, but the BP reductions are related to pre-treatment BP levels of subjects and the type of control diet used as comparison.