INTESTINAL CONTROL OF GASTRIC TONE
INTESTINAL CONTROL OF GASTRIC TONE
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DOI：
10.1152/ajpgi.1985.249.4.g501
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发表时间：
1985-01-01
影响因子：
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通讯作者：
MALAGELADA, JR
中科院分区：
文献类型：
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作者：
AZPIROZ, F;MALAGELADA, JR
利用一种新研制的电子恒压器，我们研究了食糜介导的肠道对犬胃张力的调节作用。在该模型中，近端（3只犬）或远端（3只犬）小肠被管腔隔离，保持神经肌肉连续性。通过记录胃内袋内空气体积的变化来测量胃张力，该胃内袋由电子恒压器维持在恒定压力（2 mmHg）。用等渗盐水（对照）或碳水化合物（麦芽糖）、蛋白质（酪蛋白水解物）、脂肪（油酸钠）或所有三种营养素的组合的测试输注物（渗透压，300 mosmol/kg; pH 7.4）持续灌注（5 ml/min）分离的肠袢。混合营养液，注入近端或远端肠，深刻抑制胃张力。脂肪注入近端肠道诱导胃舒张，而蛋白质只有适度的影响和碳水化合物没有影响。相反，在远端肠碳水化合物和蛋白质显着胃张力，而脂肪没有影响。我们的结论是，小肠营养调节胃张力的机制是营养和区域特异性。
By use of a newly developed electronic barostat, we investigated chyme-mediated intestinal regulation of gastric tone in a canine model. In this model the proximal (3 dogs) or distal (3 dogs) small intestine was luminally isolated, maintaining neuromuscular continuity. Gastric tone was measured by recording variations in the volume of air within an intragastric bag that was maintained at a constant pressure (2 mmHg) by the electronic barostat. The isolated intestinal loop was perfused constantly (5 ml/min) with either isotonic saline (control) or with test infusates (osmolality, 300 mosmol/kg; pH 7.4) of carbohydrate (maltose), protein (casein hydrolysate), fat (sodium oleate), or a combination of all three nutrients. The combined nutrient solution, infused into either the proximal or the distal intestine, profoundly inhibited gastric tone. Fat infused into the proximal intestine induced gastric relaxation, whereas protein had only a modest effect and carbohydrate had no effect. In contrast, in the distal intestine carbohydrate and protein markedly gastric tone, whereas fat had no effect. We conclude that nutrients in the small bowel regulate gastric tone by a mechanism that is nutrient and region specific.