ROLE OF IMMUNOLOGICAL DISTURBANCE IN HUMAN ONCOGENESIS - SOME FACTS AND FANCIES
ROLE OF IMMUNOLOGICAL DISTURBANCE IN HUMAN ONCOGENESIS - SOME FACTS AND FANCIES
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DOI：
10.1038/bjc.1971.78
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发表时间：
1971-01-01
影响因子：
8.8
通讯作者：
KAPLAN, HS
中科院分区：
文献类型：
--
作者：
KAPLAN, HS
简要回顾了某些类型的肿瘤，特别是恶性淋巴瘤的发展，在动物和人类的慢性免疫抑制和自然发生的人类免疫缺陷状态的证据。然后，讨论的重点是霍奇金病，并认为最近的证据有关的疾病的临床阶段和相关的细胞介导的免疫缺陷之间的关系。最后，先前发生的传染性单核细胞增多症在某些情况下的霍奇金病被认为是在假设的背景下，霍奇金病的肿瘤细胞可能演变成一个慢性免疫反应，类似于移植物抗宿主，源于诱导抗原改变的淋巴细胞亚群的某些类型的非肿瘤性病毒感染。
A brief review is presented of the evidence linking the development of certain types of neoplasms, and of the malignant lymphomas in particular, to chronic immunosuppression in animals and man and to the naturally occurring human immunologic deficiency states. The discussion then focuses on Hodgkin's disease and considers recent evidence concerning the relation between the clinical stage of the disease and its associated defect in cell-mediated immunity. Finally, the prior occurrence of infectious mononucleosis in some cases of Hodgkin's disease is considered in the context of the hypothesis that the neoplastic cells of Hodgkin's disease may evolve from a chronic immunologic reaction, analogous to that of graft-versus-host, stemming from the induction of antigenic alteration in a subpopulation of lymphocytes by certain types of non-neoplastic viral infections.