Early and late coronary stent thrombosis of sirolimus-eluting and paclitaxel-eluting stents in routine clinical practice:: data from a large two-institutional cohort study
Early and late coronary stent thrombosis of sirolimus-eluting and paclitaxel-eluting stents in routine clinical practice:: data from a large two-institutional cohort study
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DOI：
10.1016/s0140-6736(07)60314-6
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发表时间：
2007-02-24
期刊：
影响因子：
168.9
通讯作者：
Serruys, Patrick W.
中科院分区：
文献类型：
--
作者：
Daemen, Joost;Wenaweser, Peter;Serruys, Patrick W.
支架血栓形成是与药物洗脱支架使用相关的安全性问题。鲜为人知的是发生支架血栓形成超过1年后植入such stents.Methods之间，2002年4月，2005年12月，8146例患者接受经皮冠状动脉介入治疗西罗莫司洗脱支架（SES; n=3823）或紫杉醇洗脱支架（PES; n=4323）在两个学术医院。我们评估了该组的数据，以确定支架内血栓形成的发病率，时间进程和相关因素，以及早期（0-30天）和晚期（>30天）支架内血栓形成之间的差异，SES和PES.Findings血管造影记录支架内血栓形成发生在152例患者（发病密度1.3每100人年，3年的累积发病率为2.9%）。在91例（60%）患者中观察到早期支架内血栓形成，在61例（40%）患者中观察到晚期支架内血栓形成。支架植入后3年内，晚期支架内血栓形成以每年0.6%的恒定速率稳定发生。SES（1.1%）和PES（1.3%）的早期支架内血栓形成发生率相似，但PES（1.8%）的晚期支架内血栓形成发生率高于SES（1.4%; p=0.031）。在支架血栓形成时，87%（早期）和23%（晚期）的患者正在接受双重抗血小板治疗（p
Background Stent thrombosis is a safety concern associated with use of drug-eluting stents. Little is known about occurrence of stent thrombosis more than 1 year after implantation of such stents.Methods Between April, 2002, and Dec, 2005, 8146 patients underwent percutaneous coronary intervention with sirolimus-eluting stents (SES; n=3823) or paclitaxel-eluting stents (PES; n=4323) at two academic hospitals. We assessed data from this group to ascertain the incidence, time course, and correlates of stent thrombosis, and the differences between early (0-30 days) and late (>30 days) stent thrombosis and between SES and PES.Findings Angiographically documented stent thrombosis occurred in 152 patients (incidence density 1.3 per 100 person-years; cumulative incidence at 3 years 2.9%). Early stent thrombosis was noted in 91 (60%) patients, and late stent thrombosis in 61 (40%) patients. Late stent thrombosis occurred steadily at a constant rate of 0.6% per year up to 3 years after stent implantation. incidence of early stent thrombosis was similar for SES (1.1%) and PES (1.3%), but late stent thrombosis was more frequent with PES (1.8%) than with SES (1.4%; p=0.031). At the time of stent thrombosis, dual antiplatelet therapy was being taken by 87% (early) and 23% (late) of patients (p