Aging-related tau astrogliopathy (ARTAG): harmonized evaluation strategy.
Aging-related tau astrogliopathy (ARTAG): harmonized evaluation strategy.
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DOI：
10.1007/s00401-015-1509-x
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发表时间：
2016-01
影响因子：
12.7
通讯作者：
Dickson DW
中科院分区：
文献类型：
--
作者：
Kovacs GG;Ferrer I;Grinberg LT;Alafuzoff I;Attems J;Budka H;Cairns NJ;Crary JF;Duyckaerts C;Ghetti B;Halliday GM;Ironside JW;Love S;Mackenzie IR;Munoz DG;Murray ME;Nelson PT;Takahashi H;Trojanowski JQ;Ansorge O;Arzberger T;Baborie A;Beach TG;Bieniek KF;Bigio EH;Bodi I;Dugger BN;Feany M;Gelpi E;Gentleman SM;Giaccone G;Hatanpaa KJ;Heale R;Hof PR;Hofer M;Hortobágyi T;Jellinger K;Jicha GA;Ince P;Kofler J;Kövari E;Kril JJ;Mann DM;Matej R;McKee AC;McLean C;Milenkovic I;Montine TJ;Murayama S;Lee EB;Rahimi J;Rodriguez RD;Rozemüller A;Schneider JA;Schultz C;Seeley W;Seilhean D;Smith C;Tagliavini F;Takao M;Thal DR;Toledo JB;Tolnay M;Troncoso JC;Vinters HV;Weis S;Wharton SB;White CL 3rd;Wisniewski T;Woulfe JM;Yamada M;Dickson DW
异常磷酸化的tau蛋白在星形胶质细胞中的病理性积累是一种常见的，但缺乏表征的衰老脑的特征。其病因尚不确定，但其存在足够普遍，值得进一步表征和分类，这可能会刺激临床病理学研究和研究其病理生物学。本文旨在协调评估和命名的老化相关的tau星形胶质细胞病变（ARTAG），一个术语，是指形态光谱的星形胶质细胞病理检测tau免疫组化，特别是磷酸化依赖性和4 R亚型特异性抗体。ARTAG主要发生在60岁以上的个体中，但不限于此。ARTAG中的Tau免疫反应性星形胶质细胞包括胶质界膜和白色物质中的刺状星形胶质细胞，以及具有核周胞质Tau免疫反应性的孤立或成簇星形胶质细胞，其作为细纤维或颗粒免疫阳性延伸到星形胶质细胞突起中，通常在灰质中。不同形式的ARTAG可能共存于同一大脑中，并可能反映不同的致病过程。基于形态学和解剖学分布，ARTAG可以与原发性tau蛋白病区分开，但可能与原发性tau蛋白病或其他疾病并发。我们推荐四个步骤来评估ARTAG：（1）根据tau星形胶质细胞病变的形态学位置确定五种类型：软膜下、室管膜下、血管周围、白色物质、灰质;（2）记录区域受累：内侧颞叶、叶（额叶、顶叶、枕叶、侧颞叶）、皮质下、脑干;（3）记录tau星形胶质细胞病的严重程度;和（4）描述次区域受累。某些类型的ARTAG可能是神经系统症状的基础;然而，ARTAG的临床意义目前尚不确定，有待进一步研究。该提案的目标是提高对老年大脑中星形胶质细胞tau病理学的认识，促进神经病理学家和研究人员之间的沟通，并为临床生物标志物的解释和专注于tau相关指标的成像研究提供信息。
Pathological accumulation of abnormally phosphorylated tau protein in astrocytes is a frequent, but poorly characterized feature of the aging brain. Its etiology is uncertain, but its presence is sufficiently ubiquitous to merit further characterization and classification, which may stimulate clinicopathological studies and research into its pathobiology. This paper aims to harmonize evaluation and nomenclature of aging-related tau astrogliopathy (ARTAG), a term that refers to a morphological spectrum of astroglial pathology detected by tau immunohistochemistry, especially with phosphorylation-dependent and 4R isoform-specific antibodies. ARTAG occurs mainly, but not exclusively, in individuals over 60 years of age. Tau-immunoreactive astrocytes in ARTAG include thorn-shaped astrocytes at the glia limitans and in white matter, as well as solitary or clustered astrocytes with perinuclear cytoplasmic tau immunoreactivity that extends into the astroglial processes as fine fibrillar or granular immunopositivity, typically in gray matter. Various forms of ARTAG may coexist in the same brain and might reflect different pathogenic processes. Based on morphology and anatomical distribution, ARTAG can be distinguished from primary tauopathies, but may be concurrent with primary tauopathies or other disorders. We recommend four steps for evaluation of ARTAG: (1) identification of five types based on the location of either morphologies of tau astrogliopathy: subpial, subependymal, perivascular, white matter, gray matter; (2) documentation of the regional involvement: medial temporal lobe, lobar (frontal, parietal, occipital, lateral temporal), subcortical, brainstem; (3) documentation of the severity of tau astrogliopathy; and (4) description of subregional involvement. Some types of ARTAG may underlie neurological symptoms; however, the clinical significance of ARTAG is currently uncertain and awaits further studies. The goal of this proposal is to raise awareness of astroglial tau pathology in the aged brain, facilitating communication among neuropathologists and researchers, and informing interpretation of clinical biomarkers and imaging studies that focus on tau-related indicators.