Clinical and Virologic Studies on Female Genital Herpes
Clinical and Virologic Studies on Female Genital Herpes
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女性生殖器疱疹的临床和病毒学研究
DOI：
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发表时间：
1982
影响因子：
7.2
通讯作者：
S. Sakamoto
中科院分区：
文献类型：
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作者：
K. Kawagoe;K. Takizawa;Jui Tung Chen;Takehiro Kawaguchi;S. Sakamoto
对90例生殖器疱疹患者进行了临床和病毒学研究。从临床角度来看，这些患者可分为3种临床类型-急性，复发性和激发。当对从这些患者和无症状病毒分泌者中分离的单纯疱疹病毒（HSV）株进行分型时，36株被确定为1型（HSV-1），其余54株被确定为2型（HSV-2）。急性型主要由HSV-1或HSV-2原发感染引起，也可在无异源抗体的情况下由HSV-2感染引起。此外，从复发性、激发性和无症状病毒分泌者中分离的40株HSV中有35株被鉴定为HSV-2，表明HSV-2可能在女性生殖器区域建立潜伏感染中起主要作用。
Ninety women with genital herpes were studied clinically and virologically. From a clinical standpoint, these patients could be classified into 3 clinical types—acute, recurrent, and provoked. When herpes simplex virus (HSV) strains isolated from these patients and asymptomatic virus secretors were typed, 36 strains were determined to be type 1 (HSV-1) and the remaining 54 to be type 2 (HSV-2). The acute type was caused mainly by primary infection of HSV-1 or HSV-2 as well as by infection of HSV-2 in the absence of heterologous antibody. In addition, 35 of 40 HSV strains isolated from recurrent, provoked, and asymptomatic virus secretors were identified as HSV-2, suggesting that HSV-2 may play a major role in establishing latent infection in the female genital region.