AUDITORY TOXICITY EFFECTS OF LONG-TERM CIS-DICHLORODIAMMINEPLATINUM-II THERAPY IN GENITOURINARY CANCER-PATIENTS
AUDITORY TOXICITY EFFECTS OF LONG-TERM CIS-DICHLORODIAMMINEPLATINUM-II THERAPY IN GENITOURINARY CANCER-PATIENTS
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DOI：
10.1002/jso.2930160203
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发表时间：
1981-01-01
影响因子：
2.5
通讯作者：
METTLIN, C
中科院分区：
文献类型：
--
作者：
AGUILARMARKULIS, NV;BECKLEY, S;METTLIN, C
To determine the auditory toxicity effects of long-term cis-dichlorodiammineplatinum II therapy, pure tone hearing thresholds were measured prior to therapy and repeated before each subsequent treatment. CDDP was given by a slow i.v. drip method at a low dose of 1 mg/kg body wt, with 37.5 g mannitol, once a week for 6 treatments and every 3 wk thereafter. From a group of 173 genitourinary cancer patients treated, 50 male patients were selected who received at least 12 mo. of CDDP with no active conductive ear pathology and whose audiograms obtained at baseline, 6th wk, 26th wk and 52nd wk of treatment were all available for comparison. Pure tone threshold levels deteriorated across time particularly by the 52nd wk and at the higher frequencies. Threshold differences across time were statistically significant and within a linear trend. Of the 50 cases, 30% showed suspect or no ototoxicity, 26% mild, 32% moderate, 2% marked; 4% showed severe ototoxic changes. Of the 2 cases who developed severe ototoxicity, 1 showed complete recovery. There was partial recovery in 26% and no recovery in 54%. Individual variability in susceptibility to and recovery from ototoxicity necessitates systematic audiometric monitoring throughout the therapy.
