PARTIAL AND TOTAL LIPODYSTROPHY: CHANGES IN CIRCULATING SUGAR, FREE FATTY ACIDS, INSULIN AND GROWTH HORMONE FOLLOWING THE ADMINISTRATION OF GLUCOSE AND OF INSULIN
PARTIAL AND TOTAL LIPODYSTROPHY: CHANGES IN CIRCULATING SUGAR, FREE FATTY ACIDS, INSULIN AND GROWTH HORMONE FOLLOWING THE ADMINISTRATION OF GLUCOSE AND OF INSULIN
复制标题
部分和全部脂肪营养不良：施用葡萄糖和胰岛素后循环糖、游离脂肪酸、胰岛素和生长激素的变化
DOI：
10.1111/j.1365-2265.1973.tb00411.x
复制
发表时间：
1973
影响因子：
3.2
通讯作者：
G. Broadley
中科院分区：
文献类型：
--
作者：
B. Boucher;R. D. Cohen;R. J. Frankel;A. STUART MASON;G. Broadley
研究了葡萄糖或胰岛素给药对5例部分脂肪营养不良和3例完全脂肪营养不良患者的影响。仅1例患者葡萄糖耐量曲线异常。平均空腹血清胰岛素、生长激素、游离脂肪酸（FFA）和甘油三酯均显著升高。血清胰岛素对葡萄糖的反应明显升高。存在胰岛素抵抗。血清胰岛素显示免疫正常，外源性胰岛素以正常速率从循环中消失，表明空腹状态和葡萄糖后胰岛素水平升高是由于分泌过多。葡萄糖后血清生长激素水平不能正常抑制。血糖或胰岛素治疗后血清FFA下降。在1例接受普萘洛尔治疗的患者中，观察到对葡萄糖给药的胰岛素反应异常。提出了一个能够解释脂肪代谢障碍的代谢变化的工作假说。
The effect of glucose or insulin administration in a group of five patients with partial lipodystrophy and three with total lipodystrophy was studied. In only one patient was the glucose tolerance curve abnormal. Mean fasting serum insulin, growth hormone, free fatty acids (FFA) and triglycerides were all significantly elevated. The serum insulin response to glucose was grossly elevated. Insulin resistance was present. The serum insulin was shown to be immunologically normal, Exogenous insulin disappeared at a normal rate from the circulation, suggesting that the elevated insulin levels in the fasting state and after glucose were due to hypersecretion. Serum growth hormone levels failed to suppress normally after glucose. Serum FFA fell after glucose or insulin administration. In one patient treated with propranolol unusual insulin responses to the administration of glucose were observed. A working hypothesis capable of explaining the metabolic changes in lipodystrophy is proposed.