Platelet-rich fibrin (PRF): A second-generation platelet concentrate. Part V: Histologic evaluations of PRF effects on bone allograft maturation in sinus lift
Platelet-rich fibrin (PRF): A second-generation platelet concentrate. Part V: Histologic evaluations of PRF effects on bone allograft maturation in sinus lift
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DOI：
10.1016/j.tripleo.2005.07.012
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发表时间：
2006-03-01
期刊：
影响因子：
--
通讯作者：
Dohan, DM
中科院分区：
文献类型：
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作者：
Choukroun, J;Diss, A;Dohan, DM
Objective.富血小板纤维蛋白（PRF）属于新一代血小板浓缩物，具有简化的加工过程，无需生化血液处理。使用血小板凝胶来促进骨再生是种植学中的一项新技术。然而，这些产品的生物学特性和真实的效果仍然存在争议。因此，在这篇文章中，我们试图评估PRF联合冻干同种异体骨（FDBA）（Phoenix; TBF，法国）在窦底提升中增强骨再生的潜力。进行了9次窦底提升。在6个部位中，将PRF添加到FDBA颗粒中（试验组），在3个部位中使用不含PRF的FDBA（对照组）。试验组在4个月后，对照组在8个月后，在种植体插入过程中从增强区域采集骨样本。对这些标本进行组织学分析。组织学评价显示存在被新形成的骨和结缔组织包围的残余骨。在4个月的愈合时间后，试验组的组织学成熟似乎与对照组在8个月后的组织学成熟相同。两种方案的新骨形成量相当。使用FDBA和PRF进行窦底提升可缩短种植体植入前的愈合时间。从组织学的角度来看，这种愈合时间可以缩短到4个月，但仍需要大规模的研究来验证这些初步结果。
Objective. Platelet-rich fibrin (PRF) belongs to a new generation of platelet concentrates, with simplified processing and without biochemical blood handling. The use of platelet gel to improve bone regeneration is a recent technique in implantology. However, the biologic properties and real effects of such products remain controversial. In this article, we therefore attempt to evaluate the potential of PRF in combination with freeze-dried bone allograft (FDBA) (Phoenix; TBF, France) to enhance bone regeneration in sinus floor elevation.Study design. Nine sinus floor augmentations were performed. In 6 sites, PRF was added to FDBA particles (test group), and in 3 sites FDBA without PRF was used (control group). Four months later for the test group and 8 months later for the control group, bone specimens were harvested from the augmented region during the implant insertion procedure. These specimens were treated for histologic analysis.Results. Histologic evaluations reveal the presence of residual bone surrounded by newly formed bone and connective tissue. After 4 months of healing time, histologic maturation of the test group appears to be identical to that of the control group after a period of 8 months. Moreover, the quantities of newly formed bone were equivalent between the 2 protocols.Conclusions. Sinus floor augmentation with FDBA and PRF leads to a reduction of healing time prior to implant placement. From a histologic point of view, this healing time could be reduced to 4 months, but large-scale studies are still necessary to validate these first results.