Inhibition of mammary tumorigenesis in nulliparous C3H mice by chronic feeding of the synthetic retinoid, N-(4-hydroxyphenyl)-retinamide.
Inhibition of mammary tumorigenesis in nulliparous C3H mice by chronic feeding of the synthetic retinoid, N-(4-hydroxyphenyl)-retinamide.
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通过长期喂养合成类视黄醇 N-(4-羟苯基)-视黄酰胺，可抑制未产 C3H 小鼠的乳腺肿瘤发生。
DOI：
10.1093/carcin/4.9.1185
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发表时间：
1983
期刊：
影响因子：
4.7
通讯作者：
Moon,RC
中科院分区：
文献类型：
--
作者：
Welsch,CW;DeHoog,JV;Moon,RC
Feeding of N-(hydroxyphenyl)retinamide (4-HPR) (1.0 mM/kg diet) for 39 weeks to 2 month old nulliparous C3H/Crgl mice significantly (p<0.01) reduced the incidence of mammary tumors; 98 control mice developed a total of 235 mammary tumors, 100 4-HPR treated mice developed 171 mammary tumors. Feeding the same dietary level of 4-HPR to 4–6 month old multiparous OH mice for 14 weeks did not significantly influence the development of mammary tumors; 78 control mice developed a total of 115 mammary tumors; 78 4-HPR treated mice developed 130 mammary tumors. Body weight gains were comparable among 4-HPR treated mice and control mice. Significant suppression of mouse mammary gland tumorigenesisin vivoby dietary retinoids (nulliparous C3H mice) has heretofore not been reported.
