Interactions between environmental sensitivity and gut microbiota are associated with biomarkers of stress-related psychiatric symptoms
Interactions between environmental sensitivity and gut microbiota are associated with biomarkers of stress-related psychiatric symptoms
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DOI：
10.1101/2023.03.30.534559
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发表时间：
2023-03
期刊：
影响因子：
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通讯作者：
S. Iimura;Satoshi Takasugi;Miyabi Yasuda;Yoshie Saito;Masashi Morifuji
中科院分区：
文献类型：
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作者：
S. Iimura;Satoshi Takasugi;Miyabi Yasuda;Yoshie Saito;Masashi Morifuji
背景人类对压力和支持性环境和经历的敏感度各不相同。这种环境敏感度的个体差异与压力相关的精神症状的机制有关。近年来，研究人员将脑-肠道-微生物区轴的双向相互作用作为导致应激相关精神症状机制的一种神经生理途径，并迅速积累了证据。方法收集90例成人(女性占50%；MAGE=42.1；SDAGE=10.0)的环境敏感性、肠道微生物区系、肠道通透性(脂多糖结合蛋白；LBP)和炎症(C-反应蛋白；CRP)的数据。使用自我报告问卷测量环境敏感度。研究参与者的粪便被分析，观察到的操作分类单位的丰富度、香农的均匀指数和生物多样性的系统发育多样性被评估为肠道微生物区系的指标。此外，还对参与者的血清进行了CRP和LBP分析。我们调查了环境敏感性和肠道微生物区系之间的相互作用是否与炎症和肠道通透性的生物标记物有关。结果环境敏感性与肠道微生物区系之间的相互作用(不包括Shannon‘s指数)解释了这些生物标志物的水平。当肠道微生物区系的丰富度和多样性较低时，环境敏感度高的个体表现出较高的CRP和LBP水平。然而，当肠道微生物区系的丰富度和多样性较高时，即使是高度易感的个体也有较低的CRP和LBP水平。结论我们的研究表明，当肠道微生物区系多样性低时，高环境敏感性可能是炎症和肠道通透性的危险因素，提示脑-肠道-微生物区轴的相互作用。
Background Humans vary in their sensitivity to stressful and supportive environments and experiences. Such individual differences in environmental sensitivity are associated with mechanisms of stress-related psychiatric symptoms. In recent years, researchers have focused on bidirectional interactions in the brain-gut-microbiota axis as a neurophysiological pathway contributing to the mechanisms of stress-related psychiatric symptoms, and evidence is rapidly accumulating. Methods Data on environmental sensitivity, gut microbiota, gut permeability (lipopolysaccharide-binding protein; LBP) and inflammation (C-reactive protein; CRP) were collected from 90 adults (50% female; Mage = 42.1; SDage = 10.0). Environmental sensitivity was measured using a self-report questionnaire. Study participants’ feces were analyzed, and observed operational taxonomic units for richness, Shannon’s index for evenness, and phylogenetic diversity for biodiversity were evaluated as indicators of gut microbiota. In addition, participants’ serum was analyzed for CRP and LBP. We investigated whether the interaction between environmental sensitivity and gut microbiota is associated with biomarkers of inflammation and gut permeability. Results The interaction between environmental sensitivity and gut microbiota (excluding the Shannon’s index) explained the levels of these biomarkers. Individuals with high environmental sensitivity displayed higher levels of CRP and LBP, when the richness and diversity of the gut microbiota was low. However, even highly susceptible individuals had lower levels of CRP and LBP, when the richness and diversity of the gut microbiota was high. Conclusions Our study indicates that high environmental sensitivity can be a risk factor for inflammation and gut permeability, when the gut microbiota diversity is low, suggesting a brain-gut-microbiota axis interaction.