Association Between Left Ventricular Mass and Telomere Length in a Population Study
Association Between Left Ventricular Mass and Telomere Length in a Population Study
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DOI：
10.1093/aje/kwq142
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发表时间：
2010-08-15
影响因子：
5
通讯作者：
Samani, Nilesh J.
中科院分区：
文献类型：
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作者：
Kuznetsova, Tatiana;Codd, Veryan;Samani, Nilesh J.
实验研究表明端粒动态与心肌细胞大小和复制潜力有关。较短的端粒标志着增殖减弱和细胞凋亡增加。作者研究了这是否会转化为端粒长度 (TL) 对普通人群左心室 (LV) 质量的影响。在 334 名随机选择的佛兰德参与者（平均年龄 = 46.5 岁；52.5% 为女性）中，他们使用定量聚合酶链反应测量了循环白细胞中的 TL，将其表示为端粒/基因组 DNA 比率 (T/S)。 1996 年至 2007 年期间，经过中位 7.4 年的随访（四分位距，6.2-8.5），他们通过超声心动图测量了左室质量。在考虑性别、年龄、体重和身高、收缩压和抗高血压药物使用的多变量调整分析中，整个人群和 198 名血压正常受试者的 LV 质量和 LV 质量指数随平均白细胞 TL 显着增加。对于 T/S 比值增加 1 个标准差，所有受试者的 LV 质量（平均值 = 170 g）和 LV 质量指数（平均值 = 92 g/m(2)）分别增加 5.20 g (P = 0.003) 和 2.70 g/m(2) (P = 0.004)，并增加 8.03 g (P = 0.0001) 和血压正常受试者为 3.74 g/m(2) (P = 0.0007)。在血压正常的受试者中，与左室壁厚度（P < 0.007）有相应的相关性，但与左室内径（P = 0.26）无关。较长的平均白细胞 TL 与左心室质量增加相关，特别是在血压正常的受试者中。这种关联可能具有与 TL 在确定心肌细胞大小和复制潜力中的作用相关的生物学基础。
Experimental studies have implicated telomere dynamics in cardiomyocyte size and replication potential; shorter telomeres mark attenuated proliferation and increased apoptosis. The authors examined whether this translates into an impact of telomere length (TL) on left ventricular (LV) mass in the general population. In 334 randomly selected Flemish participants (mean age = 46.5 years; 52.5% women), they measured TL in circulating leukocytes using quantitative polymerase chain reaction, expressing it as telomere/genomic DNA ratio (T/S). After a median 7.4 years of follow-up (interquartile range, 6.2-8.5) during 1996-2007, they measured LV mass by echocardiography. In multivariable-adjusted analyses accounting for sex, age, body weight and height, systolic blood pressure, and antihypertensive drug use, LV mass and LV mass index significantly increased with mean leukocyte TL in the entire population and in the 198 normotensive subjects. For a 1-standard-deviation increment in T/S ratio, LV mass (mean = 170 g) and LV mass index (mean = 92 g/m(2)) increased by 5.20 g (P = 0.003) and 2.70 g/m(2) (P = 0.004), respectively, in all subjects and by 8.03 g (P = 0.0001) and 3.74 g/m(2) (P = 0.0007) in normotensive subjects. There were corresponding associations with LV wall thicknesses (P < 0.007) but not LV internal diameter (P = 0.26) in normotensive subjects. Longer mean leukocyte TL is associated with increased LV mass, particularly in normotensive subjects. This association could have a biologic basis related to the role of TL in determining cardiomyocyte size and replication potential.