How repeatable are the physiological effects of TENS?
How repeatable are the physiological effects of TENS?
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DOI：
10.1016/j.clinph.2008.04.002
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发表时间：
2008-08-01
影响因子：
4.7
通讯作者：
Rothwell, John C.
中科院分区：
文献类型：
--
作者：
Fernandez-del-Olmo, Miguel;Alvarez-Sauco, Maria;Rothwell, John C.
目的：一些研究表明，经皮电刺激（TENS）可以对中枢神经系统（CNS）产生各种影响。在这项研究中，我们试图复制TENS的生理效应，并探讨其对皮质内circuits.Methods的影响：我们使用经颅磁刺激（TMS）和脊髓反射测试，检查皮质内和脊髓回路的兴奋性之前和之后的30分钟期间的TENS桡侧腕屈肌（FCR）肌肉。测量桡侧腕屈肌和桡侧腕伸肌经颅磁刺激诱发的肌肉反应（MEP）、短间期皮质内抑制（SICI）、皮质内易化（ICF）和皮质拮抗抑制（CAI）的幅度（FCR，ECR）以及从ECR到FCR的脊髓相互抑制（RI）和突触前抑制（PI）。TENS没有显着影响任何这些措施，除了减少正中神经诱导的促进FCR测试CAI时。与以前的研究相比，我们的结果表明，TENS的效果是高度可变和不可靠的，可能是由于难以确定个体受试者中刺激的精确参数。重要性：应注意假设在小群体受试者中观察到的TENS后的效应同样适用于更广泛的群体。(c)2008年国际临床神经生理学联合会。由Elsevier爱尔兰有限公司出版。保留所有权利。
Objective: Several studies suggest that transcutaneous electrical stimulation (TENS) can have a variety of effects on the central nervous system (CNS). In this study, we tried to replicate the physiological effects of TENS and to explore its effects on intracortical circuits.Methods: We used transcranial magnetic stimulation (TMS) and spinal reflex testing to examine excitability of intracortical and spinal cord circuits before and after a 30-min period of TENS over the flexor carpi radialis (FCR) muscle. We measured the amplitude of TMS-evoked muscle responses (MEP), short interval intracortical inhibition (SICI), intracortical facilitation (ICF) and cortical antagonist inhibition (CAI) in flexor and extensor carpial radialis (FCR, ECR) muscles as well as spinal reciprocal inhibition (RI) and presynaptic inhibition (PI) from ECR to FCR.Results: TENS had no significant effect on any of these measures apart from a reduction in median nerve induced facilitation of FCR when testing CAI.Conclusions: When compared with previous studies, our results suggest that the effects of TENS are highly variable and unreliable, likely by the difficulty in defining precise parameters of stimulation in individual subjects.Significance: Care should be taken in assuming that effects after TENS observed in small populations of subjects will apply equally to a wider population. (c) 2008 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.