Three's company
Three's company
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三人的公司
DOI：
10.1038/nm0309-232
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发表时间：
2009
期刊：
影响因子：
82.9
通讯作者：
David F. Gruber
中科院分区：
文献类型：
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作者：
David F. Gruber
多年来，教科书将神经通信描述为一个简单的过程，其中信号只是从一个细胞跳到另一个细胞。这种传统观点也将神经胶质细胞视为神经元之间信号传递的被动旁观者。但科学家们越来越多地将神经胶质视为信号在神经元之间传递的空间中有影响力的第三个参与者，他们称之为“三重突触”。基于这一概念，一些人已经开始研究神经胶质在神经系统疾病中的作用，并开发靶向这些细胞的治疗化合物。大卫格鲁伯报道。
For many years, textbooks portrayed nerve communication as a straightforward process in which a signal simply hopped from one cell to the next. This traditional view also cast cells known as glia as passive bystanders to the signaling action between neurons. But scientists increasingly regard glia as influential third players in the space where signals pass between neurons, a space they have termed the 'tripartite synapse'. On the basis of this concept, some have begun to study the involvement of glia in nervous system disorders and to develop therapeutic compounds that target these cells. David Gruber reports.