Better prognosis in newborns with trisomy 13 who received intensive treatments: a retrospective study of 16 patients.
Better prognosis in newborns with trisomy 13 who received intensive treatments: a retrospective study of 16 patients.
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DOI：
10.1007/s12013-012-9355-0
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发表时间：
2012-07
影响因子：
2.6
通讯作者：
Arisaka, Osamu
中科院分区：
文献类型：
--
作者：
Tsukada, Keiko;Imataka, George;Suzumura, Hiroshi;Arisaka, Osamu
13 三体新生儿的强化治疗因其致命性预后而存在争议。我们报告了接受强化治疗的 13 三体患者的生活预后更好。在我们医院，我们为此类患者提供了强化管理，包括根据需要进行复苏和外科手术。在此，我们介绍了 16 例接受强化治疗的 13 三体病例的回顾性研究（1989 年至 2010 年）的结果。出生前没有被诊断出患有 13 三体症； 9 名患者是通过剖腹产分娩的，所有患者在产后复苏期间均接受了吸氧。 9例患者气管插管后使用机械通气，2例患者拔管困难时行气管切开术。预后方面，死亡9例，转院3例，出院4例。分别有 4 名和 7 名患者在出生后 7 天内死亡，30 天内死亡。 9 名患者存活时间超过 1 个月，7 名患者存活时间超过 180 天，5 名患者存活时间超过 3 年。 16 名患者的中位生存期为 733 天。与之前的数据相比，接受强化治疗的患者存活时间更长。这项研究提供了有关遗传咨询的有用信息，特别是从伦理角度来看，然后再为 13 三体性新生儿提供强化管理。
Intensive treatment for newborns with trisomy 13 is controversial because of their lethal prognosis. We report the better life prognosis of patients with trisomy 13 who received intensive treatment. At our hospital, we provided an intensive management to such patients including resuscitation and surgical procedures as required. Herein, we present the results of a retrospective study (1989–2010) of 16 trisomy 13 cases who received an intensive treatment. None was diagnosed to have trisomy 13 before birth; 9 were delivered by C-section and oxygen was administered to all patients during postpartum resuscitation. Mechanical ventilation was used in 9 patients after tracheal intubation and tracheotomy was performed in 2 patients when withdrawing of extubation was difficult. Regarding prognosis, 9 patients died, 3 were referred to another hospital, and 4 were discharged from the hospital. Four and 7 patients died within 7 and 30 days after birth, respectively. Nine patients survived for >1 month, 7 for >180 days, and 5 for >3 years. Median survival for 16 patients was 733 days. The patients who received intensive treatments survived longer compared to the previous data. This study provides useful information concerning genetic counseling, especially from an ethical point of view, before providing intensive management to newborns with trisomy 13.
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影响因子：
2
作者：
Kosho, T;Nakamura, T;Fukushima, YL
通讯作者：
Fukushima, YL
影响因子：
5.2
作者：
WYLLIE, JP;WRIGHT, MJ;HUNTER, S
通讯作者：
HUNTER, S
DOI：
10.1002/ajmg.1320490204
发表时间：
1994-01-15
期刊：
AMERICAN JOURNAL OF MEDICAL GENETICS
影响因子：
--
作者：
BATY, BJ;BLACKBURN, BL;CAREY, JC
通讯作者：
CAREY, JC
影响因子：
1.4
作者：
Lin, Hsiang-Yu;Lin, Shuan-Pei;Chan, Wai-Tao
通讯作者：
Chan, Wai-Tao
影响因子：
168.9
作者：
BOS, AP;BROERS, CJM;MOLENAAR, JC
通讯作者：
MOLENAAR, JC