Pharmacological topics of bone metabolism: recent advances in pharmacological management of osteoporosis.
Pharmacological topics of bone metabolism: recent advances in pharmacological management of osteoporosis.
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骨代谢的药理学主题：骨质疏松症药理学治疗的最新进展。
DOI：
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发表时间：
2008
影响因子：
3.5
通讯作者：
M. Itoh
中科院分区：
文献类型：
--
作者：
A. Suzuki;Sahoko Sekiguchi;Shogo Asano;M. Itoh
预防骨质疏松性骨折是社会经济的一个重要优先事项，特别是在包括日本在内的发达国家。雌激素、选择性雌激素受体调节剂 (SERM) 和双膦酸盐是骨吸收的有效抑制剂；它们对于减少绝经后妇女骨质疏松性骨折具有临床意义。然而，使用这些药物我们最多可以预防 50% 的椎骨骨折。为了获得更好的氨基双膦酸盐的依从性，每日双膦酸盐方案的使用正在转变为每周或每月的双膦酸盐方案。组织蛋白酶 K 抑制剂和 RANK-RANKL 系统调节剂都可以减少骨吸收，是未来治疗骨质疏松症的候选药物。除了骨吸收之外，我们还需要增加骨形成以预防骨质疏松性骨折，特别是骨转换率低的老年患者。在美国、欧洲和澳大利亚，他们已经开始间歇性注射甲状旁腺激素和/或口服雷奈酸锶来刺激骨形成。我们仍然需要发现新的药物来减少骨质疏松性骨折，以提高无骨折的生活质量。
The prevention of osteoporotic fracture is an essential socioeconomical priority, especially in the developed countries including Japan. Estrogen, selective estrogen-receptor modulators (SERMs), and bisphosphonate are potent inhibitors of bone resorption; and they have clinical relevance to reduce osteoporotic fractures in postmenopausal women. However, we can prevent at most 50% of vertebral fractures with these agents. For the better compliance of aminobisphosphonate, the use of a daily bisphosphonate regimen is moving to a weekly or monthly bisphosphonate regimen. Both cathepsin K inhibitors and modulators of the RANK-RANKL system, which can reduce bone resorption, are the candidates for the future treatment of osteoporosis. As well as bone resorption, we need to increase bone formation to prevent osteoporotic fractures, particularly in elderly patients with low bone turnover. In the U.S., Europe, and Australia, they have already started intermittent parathyroid hormone injection and/or oral strontium ranelate to stimulate bone formation. We still need to discover new agents to reduce osteoporotic fractures for the better quality of life without fractures.
影响因子：
1.9
作者：
J. Rosen;A. Negro-Vilar
通讯作者：
J. Rosen;A. Negro-Vilar
影响因子：
5.8
作者：
Jankowski, Catherine M.;Gozansky, Wendolyn S.;Kohrt, Wendy M.
通讯作者：
Kohrt, Wendy M.
DOI：
10.1001/jama.295.23.joc60074
发表时间：
2006-06-21
影响因子：
120.7
作者：
Vogel, Victor G.;Costantino, Joseph P.;Wolmark, Norman
通讯作者：
Wolmark, Norman