Dammarane Sapogenins Ameliorates Neurocognitive Functional Impairment Induced by Simulated Long-Duration Spaceflight.
Dammarane Sapogenins Ameliorates Neurocognitive Functional Impairment Induced by Simulated Long-Duration Spaceflight.
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DOI：
10.3389/fphar.2017.00315
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发表时间：
2017
影响因子：
5.6
通讯作者：
Li Y
中科院分区：
文献类型：
--
作者：
Wu X;Li D;Liu J;Diao L;Ling S;Li Y;Gao J;Fan Q;Sun W;Li Q;Zhao D;Zhong G;Cao D;Liu M;Wang J;Zhao S;Liu Y;Bai G;Shi H;Xu Z;Wang J;Xue C;Jin X;Yuan X;Li H;Liu C;Sun H;Li J;Li Y;Li Y
越来越多的证据表明航天复合条件下航天员会发生认知功能障碍，但其机制和对策尚需进一步探讨。在这项研究中，我们发现，在模拟长时间太空飞行环境（SLSE）下，大鼠的学习和记忆能力显着降低，其中包括微重力，隔离禁闭，噪音和昼夜节律改变。达玛烷皂甙元（DS）是达玛烷皂甙的碱性水解产物，可通过调节脑内神经递质水平和抑制SLSE诱导的神经元损伤来增强认知功能。生物信息学结合实验验证表明，SLSE诱导的认知功能障碍过程中，PI3K-Akt-mTOR通路被抑制，MAPK通路被激活，而DS显著改善了脑组织的变化。这些研究结果明确了SLSE引起的认知功能下降的特点以及DS改善认知功能下降的机制，为改善航天任务中的认知功能提供了有效的候选方法。
Increasing evidence indicates the occurrence of cognitive impairment in astronauts under spaceflight compound conditions, but the underlying mechanisms and countermeasures need to be explored. In this study, we found that learning and memory abilities were significantly reduced in rats under a simulated long-duration spaceflight environment (SLSE), which includes microgravity, isolation confinement, noises, and altered circadian rhythms. Dammarane sapogenins (DS), alkaline hydrolyzed products of ginsenosides, can enhance cognition function by regulating brain neurotransmitter levels and inhibiting SLSE-induced neuronal injury. Bioinformatics combined with experimental verification identified that the PI3K-Akt-mTOR pathway was inhibited and the MAPK pathway was activated during SLSE-induced cognition dysfunction, whereas DS substantially ameliorated the changes in brain. These findings defined the characteristics of SLSE-induced cognitive decline and the mechanisms by which DS improves it. The results provide an effective candidate for improving cognitive function in spaceflight missions.