Brief and Long Periods of Maternal Separation Affect Maternal Behavior and Offspring Behavioral Development in C57BL/6 Mice
Brief and Long Periods of Maternal Separation Affect Maternal Behavior and Offspring Behavioral Development in C57BL/6 Mice
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DOI：
10.1002/dev.21135
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发表时间：
2014-05-01
影响因子：
2.2
通讯作者：
Tyler, Amber N.
中科院分区：
文献类型：
--
作者：
Bailoo, Jeremy D.;Jordan, Richard L.;Tyler, Amber N.
对于大鼠来说，母体对短期和长期母鼠分离的调节被认为是造成幼鼠成年情绪差异的原因。在本研究中，将早期处理 (EH)、母体分离 (MS) 和母体同伴分离 (MPS) 组与动物设施饲养 (AFR) 组的 C57BL/6 小鼠的母体行为和后代成年旷场行为进行比较。尽管 MS 和 MPS 母鼠在团聚时表现出更高水平的母性行为，但这些群体差异并不能预测后代的旷场行为。然而，当将后代行为作为母亲行为特定方面的函数进行分析时，无论治疗组如何，接受高水平静态护理和活动但不舔舐的幼崽情绪较低。母体舔幼崽的个体差异预示着 AFR 和 EH 幼崽情绪行为的变化。因此，对于这种小鼠品系，孕产妇护理方面的个体差异而非治疗差异可以预测后代的情绪发展。 (c) 2013 年 Wiley 期刊公司。Dev Psychobiol 56：674-685，2014 年。
For rats, maternal mediation of brief and longer term dam-pup separations were thought to account for pup differences in adult emotionality. In this study, early handling (EH), maternal separation (MS), and maternal peer separation (MPS) groups were compared to an animal facility reared (AFR) group for maternal behavior and offspring adult open-field behavior in C57BL/6 mice. Although MS and MPS dams displayed higher levels of maternal behavior upon reunion, these group differences did not predict offspring open-field behavior. However, when offspring behavior was analyzed as a function of specific aspects of maternal behavior, irrespective of treatment group, pups that received high levels of quiescent nursing and activity, but not licking, were less emotional. Individual differences in maternal licking of pups predicted variability of emotional behavior for AFR and EH pups. Thus, for this strain of mouse, individual and not treatment differences in maternal care predict offspring emotional development. (c) 2013 Wiley Periodicals, Inc. Dev Psychobiol 56: 674-685, 2014.