DNA METHYLATION AND GENE-FUNCTION
DNA METHYLATION AND GENE-FUNCTION
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DOI：
10.1126/science.6254144
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发表时间：
1980-01-01
期刊：
影响因子：
56.9
通讯作者：
RIGGS, AD
中科院分区：
文献类型：
--
作者：
RAZIN, A;RIGGS, AD
在大多数高等生物中，DNA在合成后通过许多胞嘧啶残基的酶转化为5-甲基胞嘧啶而被修饰。几年来，通过DNA甲基化控制基因活性在逻辑上被认为是一种有吸引力的可能性，但事实证明，实验支持是难以捉摸的。DNA甲基化可能是控制脊椎动物基因功能和分化的控制机制体系中的一个关键因素。
In most higher organisms, DNA is modified after synthesis by the enzymatic conversion of many cytosine residues to 5-methylcytosine. For several years, control of gene activity by DNA methylation has been recognized as a logically attractive possibility, but experimental support has proved elusive. DNA methylation may be a key element in the hierarchy of control mechanisms that govern vertebrate gene function and differentiation.