Building a better antibody through the Fc: advances and challenges in harnessing antibody Fc effector functions for antiviral protection.
Building a better antibody through the Fc: advances and challenges in harnessing antibody Fc effector functions for antiviral protection.
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DOI：
10.1080/21645515.2021.1976580
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发表时间：
2021-11-02
影响因子：
4.8
通讯作者：
Bai S
中科院分区：
文献类型：
--
作者：
Gunn BM;Bai S
抗体可以通过Fc结构域中和和募集先天效应子功能来提供抗病毒保护。虽然中和作用在抗体介导的保护中的作用长期以来一直受到重视，但越来越多的工作表明抗体Fc结构域也显着有助于抗病毒保护。抗体募集天然免疫细胞如自然杀伤细胞、中性粒细胞、单核细胞、巨噬细胞、树突细胞和补体系统可导致直接限制病毒感染以及促进长期抗病毒免疫。针对病毒的单克隆抗体治疗剂越来越多地结合Fc增强特征以利用Fc结构域，揭示了抗体可以控制病毒感染的令人惊讶的广泛机制。在这里，我们回顾了我们对抗体介导的先天免疫效应器功能在保护免受病毒感染方面的最新进展，并回顾了通过抗体有效利用先天免疫细胞的当前方法和挑战。
Antibodies can provide antiviral protection through neutralization and recruitment of innate effector functions through the Fc domain. While neutralization has long been appreciated for its role in antibody-mediated protection, a growing body of work indicates that the antibody Fc domain also significantly contributes to antiviral protection. Recruitment of innate immune cells such as natural killer cells, neutrophils, monocytes, macrophages, dendritic cells and the complement system by antibodies can lead to direct restriction of viral infection as well as promoting long-term antiviral immunity. Monoclonal antibody therapeutics against viruses are increasingly incorporating Fc-enhancing features to take advantage of the Fc domain, uncovering a surprising breadth of mechanisms through which antibodies can control viral infection. Here, we review the recent advances in our understanding of antibody-mediated innate immune effector functions in protection from viral infection and review the current approaches and challenges to effectively leverage innate immune cells via antibodies.
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影响因子：
6.7
作者：
Balsitis SJ;Williams KL;Lachica R;Flores D;Kyle JL;Mehlhop E;Johnson S;Diamond MS;Beatty PR;Harris E
通讯作者：
Harris E
影响因子：
4.3
作者：
BRAAKMAN, E;VANDEWINKEL, JGJ;BOLHUIS, RLH
通讯作者：
BOLHUIS, RLH
大小依赖性分离控制巨噬细胞对抗体调理靶标的吞噬作用。
影响因子：
64.5
作者：
Bakalar MH;Joffe AM;Schmid EM;Son S;Podolski M;Fletcher DA
通讯作者：
Fletcher DA
DOI：
10.1126/science.abc7303
发表时间：
2021-06-04
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Bournazos S;Vo HTM;Duong V;Auerswald H;Ly S;Sakuntabhai A;Dussart P;Cantaert T;Ravetch JV
通讯作者：
Ravetch JV
影响因子：
29.7
作者：
Bournazos S;Wang TT;Dahan R;Maamary J;Ravetch JV
通讯作者：
Ravetch JV