Effects of Oseltamivir phosphate (Tamiflu) and its metabolite (GS4071) on monoamine neurotransmission in the rat brain
Effects of Oseltamivir phosphate (Tamiflu) and its metabolite (GS4071) on monoamine neurotransmission in the rat brain
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DOI：
10.1248/bpb.30.1816
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发表时间：
2007-09-01
影响因子：
2
通讯作者：
Uehara, Shin-Ichi
中科院分区：
文献类型：
--
作者：
Satoh, Kanako;Nonaka, Ryouichi;Uehara, Shin-Ichi
由于服用磷酸奥司他韦（达菲）治疗流感感染的10至19岁患者出现从阳台跳下、坠落等异常行为，日本厚生劳动省通知，10至19岁患者原则上不应服用达尼福。为了研究达菲与异常行为之间的关系，我们使用大鼠大脑研究了达菲及其羧酸代谢物 GS4071 对中枢神经系统的影响，即对突触前（抑制再摄取、促进释放）和突触后（鸟苷 5'三磷酸 (GTP) γ S 结合）中的 3 种神经递质（多巴胺、血清素和去甲肾上腺素）的影响突触体。达菲和 GS4071 都不影响突触后 3 种单胺或 GTP 结合的重新摄取/释放。
As abnormal behaviors such as jumping and failing from balcony were reported in patients aged 10 to 19 years who administrated oseltarnivir phosphate (Tamiflu) for treatment influenza infection, the Ministry of Health, Labor and Welfare in Japan notified that, as a rule, Tarniflu should not be prescribed to patients aged 10 to 19 years. To examine the relationship between Tamiflu and abnormal behaviors, we investigated the effects of Tamiflu and its carboxylic acid metabolite, GS4071, on the central nervous system, that is, on 3 neurotransmitters (dopamme, serotonin, and norepinephrine) in presynapses (inhibition of reuptake, promotion of release) and postsynapses (guanosine 5'triphosphate (GTP) gamma S binding), using rat brain synaptosomes. Neither Tamiflu nor GS4071 influenced the re-uptake/release of the 3 monoamines or GTP binding in postsynapses.