Robust perfect adaptation in bacterial chemotaxis through integral feedback control
Robust perfect adaptation in bacterial chemotaxis through integral feedback control
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DOI：
10.1073/pnas.97.9.4649
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发表时间：
2000-04-25
影响因子：
11.1
通讯作者：
Doyle, J
中科院分区：
文献类型：
--
作者：
Yi, TM;Huang, Y;Doyle, J
积分反馈控制是一种基本的工程策略，用于确保系统输出鲁棒地跟踪其期望值，而不受噪声或系统参数变化的影响。在生物系统中，即使在信号持续存在的情况下，对细胞外刺激的反应也会恢复到刺激前的值，这一过程被称为适应或脱敏。Barkai, Alon， Surette和Leibler提供了理论和实验证据，证明细菌趋化性适应的精度对该信号网络中组成蛋白的水平和动力学速率常数的急剧变化是强大的[Alon]。U.，苏雷特，M. G.，巴凯。李志强，李志强（1998）《自然》杂志，第3卷第1期，168-171页。本文提出了完全自适应的鲁棒性是该系统具有积分反馈控制特性的结果。利用控制和动力系统理论的技术，我们证明了整体控制在Barkai-Leibler模型中是结构固有的，并识别和表征了模型的关键假设。最重要的是，我们认为某种形式的整体控制对于完美适应的稳健实施是必要的。更一般地说，积分控制可能是许多稳态机制稳健性的基础。
Integral feedback control is a basic engineering strategy for ensuring that the output of a system robustly tracks its desired value independent of noise or variations in system parameters. In biological systems, it is common for the response to an extracellular stimulus to return to its prestimulus value even in the continued presence of the signal-a process termed adaptation or desensitization. Barkai, Alon, Surette, and Leibler have provided both theoretical and experimental evidence that the precision of adaptation in bacterial chemotaxis is robust to dramatic changes in the levels and kinetic rate constants of the constituent proteins in this signaling network [Alon. U., Surette, M. G., Barkai. N. & Leibler, S. (1998) Nature (London) 397, 168-171]. Here we propose that the robustness of perfect adaptation is the result of this system possessing the property of integral feedback control. Using techniques from control and dynamical systems theory, we demonstrate that integral control is structurally inherent in the Barkai-Leibler model and identify and characterize the key assumptions of the model. Most importantly, we argue that integral control in some form is necessary for a robust implementation of perfect adaptation. More generally, integral control may underlie the robustness of many homeostatic mechanisms.