Degradable photothermal bioactive glass composite hydrogel for the sequential treatment of tumor-related bone defects: From anti-tumor to repairing bone defects
Degradable photothermal bioactive glass composite hydrogel for the sequential treatment of tumor-related bone defects: From anti-tumor to repairing bone defects
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DOI：
10.1016/j.cej.2021.129520
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发表时间：
2021
影响因子：
15.1
通讯作者：
Zhen Yang;Fujian Zhao;Wen Zhang;Zhengyu Yang;Man Luo;Lu Liu;Xiaodong Cao;Dafu Chen;
中科院分区：
文献类型：
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作者：
Zhen Yang;Fujian Zhao;Wen Zhang;Zhengyu Yang;Man Luo;Lu Liu;Xiaodong Cao;Dafu Chen;
治疗肿瘤相关的不规则骨缺损，术后植入的生物材料应联合收割机肿瘤治疗和骨再生的功能。为了满足这一要求，采用Diels-Alder（DA）反应和离子交联法制备了呋喃-海藻酸钠/双马来酰亚胺-聚乙二醇/铜掺杂生物活性微晶玻璃微球（SA/PEG-CuBGM）双交联可注射复合水凝胶。制备的复合水凝胶显示出良好的光热效应，在体外杀死了大部分肿瘤细胞，并在植入早期抑制了小鼠肿瘤的生长。光热效应来源于铜离子掺杂在生物活性玻璃中形成的氧化物，光热温度可以通过CuBGM浓度和近红外（NIR）功率密度来控制。其次，随着材料的降解，光热剂浓度迅速降低。此外，从CuBGM释放的Ca、Si和Cu通过上调骨相关基因表达来提高刺激mBMSCs成骨分化的能力，显著促进大鼠股骨缺损模型中的新骨形成。因此，随着光热治疗和促进成骨的顺序进展的实现，SA/PEG-CuBGM复合水凝胶将显示出相当大的潜力，以帮助开发和应用植入生物材料的肿瘤相关的骨缺损。
To treat tumor-related irregular bone defects, the implanted biomaterials after surgery should combine the functions of both tumor therapy and bone regeneration. To address the requirement, double crosslinking injectable composite hydrogels based on Furan-Sodium Alginate/bis-maleimide-Polyethylene Glycol/Copper doped Bioactive Glass-ceramic Microspheres (SA/PEG-CuBGM) were prepared using Diels–Alder (DA) reaction and ionic crosslinking. The prepared composite hydrogel showed excellent photothermal effects and killed most tumor cellsin vitroand inhibited tumor growth in mice at the early implantation stage. The photothermal effects were derived from the oxide formed by doping copper ions in bioactive glass, and the photothermal temperature could be controlled by the CuBGM concentration and power densities of near infrared (NIR). Next, the photothermal agent concentration decreased rapidly with the degradation of the material. Additionally, the Ca, Si and Cu released from CuBGM improved the capability to stimulate the osteogenic differentiation of mBMSCs by upregulating bone-related gene expression, significantly promoting new bone formation in a femoral defect model of rats. Therefore, as the sequential progress of photothermal treatment and osteogenesis promotion is realized, the SA/PEG-CuBGM composite hydrogel will demonstrate considerable potential to aid the development and application of implanted biomaterials to tumor-related bone defects.