Alteration of arterial gas composition by positive pressure ventilation in the unanesthetized fetal lamb in utero.
Alteration of arterial gas composition by positive pressure ventilation in the unanesthetized fetal lamb in utero.
复制标题
子宫内未麻醉胎羔通过正压通气改变动脉气体成分。
DOI：
10.1159/000242131
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Faber,JJ
中科院分区：
文献类型：
--
作者：
Willis,DM;Anderson,DF;Thornburg,KL;Faber,JJ
为了研究宫内通气改变胎儿动脉气体成分的有效性，我们用一系列吸入的气体混合物对15只近足月胎羊进行通气。为了实现这一目标，通过手术将双腔鼻胃管放置在15只近期（妊娠135天）胎羊的气管中。术后4 ± 1 SD，胎儿通过正压通气进行呼吸。其中13只胎仔还在脐带完全闭塞的情况下进行了通气。维持通气平均4.5 h（范围2.5-7.5 h）。当暴露于较小的呼气末正压时，所有15只胎仔在室内空气中均得到有效氧合。在脐带完整的胎儿中，通过气体混合装置改变吸入的O2和CO2，可将PaO 2维持在11 ~ 280 mmHg之间，PaCO 2维持在36 ~ 139 mmHg之间。在脐带阻断期间，PaO 2从2.2调节至103 mm Hg，PaCO 2从37调节至187 mm Hg。
To study the effectiveness of in utero ventilation in altering fetal arterial gas composition, we ventilated 15 near-term fetal lambs with a range of inspired gas mixtures. To accomplish this, double lumen nasogastric tubes were surgically placed in the tracheas of 15 near-term (135 days’ gestation) fetal lambs. After 4 ± 1 SD postoperative days, the fetuses were respired by positive pressure ventilation. 13 of these fetuses were also ventilated with their umbilical cords completely occluded. Ventilation was maintained for an average of 4.5 h (range 2.5–7.5 h). All 15 fetuses were effectively oxygenated on room air when exposed to a small net positive end expiratory pressure. In fetuses with intact umbilical cords, PaO2could be maintained at levels between 11 and 280 mm Hg and PaCO2from 36 to 139 mm Hg by altering the inspired O2and CO2with a gas mixing device. During umbilical cord occlusion, PaO2was regulated from 2.2 to 103 mm Hg and PaCO2from 37 to 187 mm Hg.