Brain transcriptomics of agonistic behaviour in the weakly electric fish Gymnotus omarorum, a wild teleost model of non-breeding aggression
Brain transcriptomics of agonistic behaviour in the weakly electric fish Gymnotus omarorum, a wild teleost model of non-breeding aggression
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DOI：
10.1038/s41598-020-66494-9
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发表时间：
2020-06-11
影响因子：
4.6
通讯作者：
Silva, Ana
中科院分区：
文献类型：
--
作者：
Eastman, Guillermo;Valino, Guillermo;Silva, Ana
社会地位的差异往往是由竞争对手之间的对抗所调解的。大量的文献研究了脊椎动物的社会地位依赖的大脑基因表达谱，但社会地位和生殖状态经常混淆。因此，确定独立于生殖状态的社会地位的神经分子机制一直具有挑战性。弱电鱼裸鱼（Gymnotus omarorum）表现出独立于生殖状态的领土侵略和社会优势。我们使用野生衍生的黄斑黄斑雄性进行非繁殖社会优势关系的转录组学分析。在允许配对的竞争对手建立优势等级之后，我们对优势个体和从属个体包含视前区（涉及调节攻击行为的区域）的大脑部分的转录组进行了分析。我们鉴定了16个差异表达基因（FDR）
Differences in social status are often mediated by agonistic encounters between competitors. Robust literature has examined social status-dependent brain gene expression profiles across vertebrates, yet social status and reproductive state are often confounded. It has therefore been challenging to identify the neuromolecular mechanisms underlying social status independent of reproductive state. Weakly electric fish, Gymnotus omarorum, display territorial aggression and social dominance independent of reproductive state. We use wild-derived G. omarorum males to conduct a transcriptomic analysis of non-breeding social dominance relationships. After allowing paired rivals to establish a dominance hierarchy, we profiled the transcriptomes of brain sections containing the preoptic area (region involved in regulating aggressive behaviour) in dominant and subordinate individuals. We identified 16 differentially expressed genes (FDR