Brains for Dementia Research: Evolution in a Longitudinal Brain Donation Cohort to Maximize Current and Future Value.
Brains for Dementia Research: Evolution in a Longitudinal Brain Donation Cohort to Maximize Current and Future Value.
复制标题
DOI：
10.3233/jad-180699
复制
发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Hayes GM
中科院分区：
文献类型：
--
作者：
Francis PT;Costello H;Hayes GM
脑库有着悠久而杰出的历史，对我们了解人类的神经和精神疾病做出了巨大贡献。脑库在操作上一直是多样化的，主要收集终末期疾病，提供不同质量的临床数据，但现在人们认识到，最有信息量的脑捐赠来自那些进行纵向研究的队列中的人。痴呆症大脑研究(BDR)队列和计划是为五个英国脑库和一个捐赠点计划的大脑捐赠，具有标准化的操作程序，之后对没有认知障碍的人以及痴呆症患者进行纵向临床和心理测量评估。有痴呆症经验的业外代表从BDR开始就参与了，所有关于参与的查询中，有74.5%是通过直接归因于业外代表或受业外代表影响的途径进行的。在开始十年后，这个正在进行的项目已经从3276名潜在的脑捐赠者中招募了700多名脑捐赠者。在本文的队列普查中，通过评估，72.2%的生活队列没有认知障碍，而捐赠的队列中只有28.3%没有认知障碍。重要的是，脑库是灵活的，并反映了研究界不断变化的需求，因为“大数据”、就绪队列和GWAs需要大量高度特征化的个体样本，以促进新的方法和对痴呆症病理过程的理解。
Brain banking has a long and distinguished past, contributing greatly to our understanding of human neurological and psychiatric conditions. Brain banks have been operationally diverse, collecting primarily end stage disease, with variable quality clinical data available, yet it is now recognized the most informative brain donations are from those in longitudinally studied cohorts. The Brains for Dementia Research (BDR) cohort and program was for planned brain donation across five UK brain banks and one donation point, with standardized operating procedures, following longitudinal clinical and psychometric assessments for people with no cognitive impairment as well as those with dementia. Lay representatives with experience of dementia were involved from inception of BDR and 74.5% of all enquiries about participation came through routes that were directly attributable to or influenced by lay representatives. Ten years after inception, this ongoing project has received over 700 brain donations from the recruited cohort of 3,276 potential brain donors. At cohort census for this paper, 72.2% of the living cohort have no cognitive impairment by assessment, whereas only 28.3% of the donated cohort were without cognitive impairment. It is important that brain banks are agile and reflect the changing needs of the research community, given that ‘big data’, readiness cohorts, and GWAS demand large sample numbers of highly characterized individuals to facilitate new approaches and understanding of pathological processes in dementia.